Non-alcoholic fatty liver disease: Insights from sphingolipidomics

Biochemical and Biophysical Research Communications
David J MontefuscoL A Cowart

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a major clinical concern and its treatment consumes abundant resources. While accumulation of lipids in hepatocytes initiates the disease, this in itself is not necessarily harmful; rather, initiation of inflammation and subsequent fibrosis and cirrhosis are critical steps in NAFLD pathology. Mechanisms linking lipid overload to downstream disease progression are not fully understood; however, bioactive lipid metabolism may underlie instigation of proinflammatory signaling. With the advent of high-throughput, sensitive, and quantitative mass spectrometry-based methods for assessing lipid profiles in NAFLD, several trends have emerged, including that increases in specific sphingolipids correlate with the transition from the relatively benign condition of simple fatty liver to the much more concerning inflamed state. Continued studies that implement sphingolipid profiling will enable the extrapolations of candidate enzymes and pathways involved in NAFLD, either in biopsies or plasma from human samples, and also in animal models, from which data are much more abundant. While most data thus far are derived from targeted lipidomics approaches, unbiased, semi-quantitative approaches hold a...Continue Reading

References

Jul 12, 2003·The Journal of Biological Chemistry·Benjamin J PettusCharles E Chalfant
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Jul 11, 2006·Methods : a Companion to Methods in Enzymology·Jacek BielawskiAlicja Bielawska
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
Feb 19, 2008·Journal of Lipid Research·Vitali MatyashDominik Schwudke
Aug 4, 2009·The Journal of Biological Chemistry·Thorsten HornemannArnold von Eckardstein
Sep 5, 2009·The American Journal of Pathology·Changyong LiLiying Li
Sep 26, 2009·The Journal of Biological Chemistry·Albert GubernEnrique Claro
Jan 26, 2010·The Journal of Biological Chemistry·Anke PennoThorsten Hornemann
Mar 17, 2010·Journal of Lipid Research·Max SchererGerhard Liebisch
May 28, 2010·The Journal of Biological Chemistry·Kenneth GableTeresa M Dunn
Aug 18, 2010·Lipids in Health and Disease·Mariana BerteaThorsten Hornemann
Mar 30, 2011·Journal of Lipid Research·Jeroen van SmedenJoke A Bouwstra
Jun 10, 2011·Mass Spectrometry Reviews·Robert C Murphy, Paul H Axelsen
Jun 23, 2011·The Journal of Biological Chemistry·Yusuf A Hannun, Lina M Obeid
Jul 12, 2011·Biochimica Et Biophysica Acta·Hany FarwanahKonrad Sandhoff
Feb 24, 2012·Journal of the American Society for Mass Spectrometry·Mathieu GaudinOlivier Laprévote
Apr 3, 2012·FEBS Letters·Susumu MitsutakeYasuyuki Igarashi
Jun 6, 2014·Nature·Michael Maceyka, Sarah Spiegel
Jan 20, 2015·Journal of Lipid Research·D Lee GordenH Alex Brown
Jan 21, 2015·Biochimica Et Biophysica Acta·Jessica SeeßleWalee Chamulitrat
Jan 28, 2016·American Journal of Physiology. Endocrinology and Metabolism·Rainey E PattersonNishanth E Sunny
Feb 13, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Nandini MondalSriram Neelamegham
Apr 7, 2016·Journal of Lipid Research·Petra HirsovaHarmeet Malhi

❮ Previous
Next ❯

Citations

Aug 28, 2020·Frontiers in Endocrinology·Annelise M Poss, Scott A Summers
Dec 2, 2020·PloS One·Hugues BeaufrèreKen D Stark
Feb 9, 2021·Frontiers in Medicine·Ralf A Claus, Markus H Graeler
Dec 17, 2020·Animals : an Open Access Journal From MDPI·Minmeng ZhaoDaoqing Gong
Mar 5, 2021·The Journal of Biological Chemistry·Velayoudame ParthibaneJairaj K Acharya
Aug 14, 2021·Journal of Lipid Research·Olga VvedenskayaAndrej Shevchenko

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The American Journal of Clinical Nutrition
Elmar AignerGuenter Weiss
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Cynthia A Moylan, Manal F Abdelmalek
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
Xiao-fei HongYou-Ming Li
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Miriam B Vos
© 2022 Meta ULC. All rights reserved