PMID: 25773826Mar 17, 2015Paper

Non-alcoholic fatty liver disease (NAFLD) and significant hepatic fibrosis defined by non-invasive assessment in patients with type 2 diabetes

Asian Pacific Journal of Cancer Prevention : APJCP
Abhasnee SobhonslidsukSupanna Petraksa

Abstract

Non-alcoholic fatty liver disease (NAFLD), the most common liver problem in diabetes, is a risk factor for liver cancer. Diabetes, high body mass index (BMI) and old age can all contribute to NAFLD progression. Transient elastography (TE) is used for non-invasive fibrosis assessment. To identify the prevalence of NAFLD and significant hepatic fibrosis in diabetic patients and to assess associated factors. One hundred and forty-one diabetic and 60 normal subjects were screened. Fatty liver was diagnosed when increased hepatic echogenicity and vascular blunting were detected by ultrasonography. Liver stiffness measurement (LSM) representing hepatic fibrosis was assessed by TE. LSM ≥7 kPa was used to define significant hepatic fibrosis. Four cases were excluded due to positive hepatitis B viral markers and failed TE. Diabetic patients had higher BMI, systolic blood pressure, waist circumference and fasting glucose levels than normal subjects. Fatty liver was diagnosed in 82 (60.7%) diabetic patients but in none of the normal group. BMI (OR: 1.31; 95%CI: 1.02-1.69; p=0.038) and alanine aminotransferase (ALT)(OR: 1.14; 95%CI: 1.05-1.23; p=0.002) were associated with NAFLD. Diabetic patients with NAFLD had higher LSM than those witho...Continue Reading

References

Dec 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M R TeliC P Day
Feb 15, 2001·The New England Journal of Medicine·A A BravoS Chopra
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Zobair M YounossiArthur J McCullough
Sep 27, 2005·Lancet·K George M M AlbertiUNKNOWN IDF Epidemiology Task Force Consensus Group
Oct 18, 2005·Alimentary Pharmacology & Therapeutics·M TrombettaM Muggeo
Nov 15, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Okka W HamerClaude B Sirlin
Mar 30, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul AnguloChristopher P Day
Mar 28, 2008·Current Diabetes Reports·Martin AdielsJan Borén
Apr 4, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Nathalie C LeiteClaudia R L Cardoso
Jun 6, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Sophie JacqueminetThierry Poynard
Mar 6, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Kenneth Cusi
Jan 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Vincent Wai-Sun WongVictor de Lédinghen
May 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ruben HernaezJeanne M Clark
May 29, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jing GaoYong-Bing Xiang
Aug 16, 2012·Clinical and Molecular Hepatology·Kyu Sik Jung, Seung Up Kim
May 30, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Krittapong SomboonRatha-Korn Vilaichone
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Vahdat PoortahmasebiSeyed Mohammad Jazayeri

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Citations

Sep 1, 2015·Asian Pacific Journal of Tropical Medicine·Dong-Fang ZhangRan Li
Jun 25, 2016·European Journal of Gastroenterology & Hepatology·Ioannis C VarbobitisGeorge V Papatheodoridis
Apr 24, 2018·BioMed Research International·Abhasnee SobhonslidsukBoonsong Ongphiphadhanakul
Jun 24, 2017·Middle East Journal of Digestive Diseases·Behnam RabieeFarhad Zamani

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