Non-alcoholic fatty liver disease: Prevalence and all-cause mortality according to sedentary behaviour and cardiorespiratory fitness. The HUNT Study

Progress in Cardiovascular Diseases
Ilaria CrociUlrik Wisloff

Abstract

Sedentary behaviour (SB) and low physical activity (PA) are independently associated with non-alcoholic fatty liver disease (NAFLD). Compared to PA, high cardiorespiratory fitness (CRF) has been associated with a higher protection against all-cause mortality and a number of specific diseases. However, this relationship has not been investigated in NAFLD. This study examined the roles of SB and CRF on: i) the likelihood of having NAFLD in the general population, and ii) the risk of mortality over 9 years within individuals having NAFLD. A cross-sectional analysis of 15,781 adults (52% female; age range 19-95 years) was conducted. Self-reported SB was divided into tertiles. CRF was estimated using validated non-exercise models, and the presence of NAFLD from the Fatty Liver Index. Adjusted Odds Ratios and 95% Confidence Intervals for NAFLD were estimated using logistic regression analyses. Hazard Ratios for all-cause mortality were estimated using Cox proportional hazard regression in individuals with NAFLD. For each additional 1 h/d of SB, the likelihood of having NAFLD was significantly increased by 4% (CI, 3-6%). In combined analyses, compared with the reference group [high CRF and low (≤4 h/d) SB], individuals with low CRF ha...Continue Reading

References

May 20, 1998·Diabetes Care·I J PerryA G Shaper
Apr 27, 2001·Medicine and Science in Sports and Exercise·P T Williams
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Jan 5, 2005·The American Journal of Medicine·Jonathan MyersVictor Froelicher
May 17, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giorgio BedogniStefano Bellentani
Apr 23, 2008·Scandinavian Journal of Public Health·Nanna KurtzeW Dana Flanders
Aug 7, 2008·Journal of Hepatology·Janus P OngZobair M Younossi
Mar 18, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amalia GastaldelliUNKNOWN RISC Investigators
Apr 7, 2009·Medicine and Science in Sports and Exercise·Peter T KatzmarzykClaude Bouchard
May 21, 2009·JAMA : the Journal of the American Medical Association·Satoru KodamaHirohito Sone
Oct 1, 2010·The New England Journal of Medicine·Giovanni TargherEnzo Bonora
Jan 14, 2011·Medicine and Science in Sports and Exercise·Stian Thoresen AspenesUlrik Wisløff
Apr 20, 2011·Medicine and Science in Sports and Exercise·Bjarne Martens NesUlrik Wisløff
Dec 22, 2011·JAMA : the Journal of the American Medical Association·Javaid NaumanUlrik Wisløff
Aug 11, 2012·International Journal of Epidemiology·S KrokstadJ Holmen
Jan 29, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Edith M KoehlerHarry L A Janssen
May 25, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rae-Chi HuangLeon A Adams
Mar 1, 2014·Medicine and Science in Sports and Exercise·Bjarne Martens NesUlrik Wisløff
Mar 4, 2014·International Journal of Epidemiology·Setor K KunutsorJohn Walley
Jan 21, 2015·Alimentary Pharmacology & Therapeutics·E Vanni, E Bugianesi
Sep 20, 2015·Journal of Hepatology·Seungho RyuYeon Soo Kim
Nov 21, 2015·Medicine and Science in Sports and Exercise·Javaid NaumanUlrik Wisløff
Apr 12, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver (EASL)UNKNOWN European Association for the Study of Obesity (EASO)
Jun 4, 2016·Journal of Hepatology·Ki-Chul SungChristopher D Byrne
Jul 13, 2016·Journal of Hepatology·E BugianesiH Cortez-Pinto
Apr 12, 2017·Medicine and Science in Sports and Exercise·Kristiina S PälveOlli T Raitakari

❮ Previous
Next ❯

Citations

Oct 28, 2019·Journal of Clinical Medicine·Rubén Fernández-RodríguezVicente Martínez-Vizcaíno
Jul 25, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Paul R AfolabiChristopher D Byrne
Jul 28, 2020·Alimentary Pharmacology & Therapeutics·Philip O'GormanSuzanne Norris
Nov 19, 2019·Canadian Journal of Gastroenterology & Hepatology·Hongjie OuXiaolu Wu
Jan 20, 2021·BMJ : British Medical Journal·Maria Letizia PetroniGiulio Marchesini
Jul 20, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Donghee KimAijaz Ahmed
Mar 27, 2021·Current Hepatology Reports·Audrey Thorp, Jonathan G Stine
Aug 4, 2021·Physiological Reports·Luma MeloJames E Klaunig
Aug 20, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Mariana Verdelho Machado
Aug 25, 2021·Journal of Gastroenterology and Hepatology·Catherine J KerrLee Ingle
Dec 11, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael H LeMindie H Nguyen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Medicine and Science in Sports and Exercise
Javaid NaumanUlrik Wisløff
Clinica Chimica Acta; International Journal of Clinical Chemistry
Ji Sun NamJong Suk Park
Hepatology Research : the Official Journal of the Japan Society of Hepatology
Aya HirataTomonori Okamura
European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology
Mette AadahlTorben Jørgensen
© 2022 Meta ULC. All rights reserved