Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

Nature Reviews. Drug Discovery
G MussoR Gambino

Abstract

Non-alcoholic fatty liver disease - the most common chronic liver disease - encompasses a histological spectrum ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Over the next decade, NASH is projected to be the most common indication for liver transplantation. The absence of an effective pharmacological therapy for NASH is a major incentive for research into novel therapeutic approaches for this condition. The current focus areas for research include the modulation of nuclear transcription factors; agents that target lipotoxicity and oxidative stress; and the modulation of cellular energy homeostasis, metabolism and the inflammatory response. Strategies to enhance resolution of inflammation and fibrosis also show promise to reverse the advanced stages of liver disease.

References

Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·R Y YangF T Liu
Aug 9, 2002·Journal of Medicinal Chemistry·Roberto PellicciariTimothy M Willson
Aug 2, 2003·Gastroenterology·Thierry ClaudelBart Staels
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Esther TitosJoan Rodés
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Emilia IpIsabelle Leclercq
May 18, 2004·The Journal of Clinical Investigation·Mitsuhiro WatanabeJohan Auwerx
Oct 12, 2004·Biochemical and Biophysical Research Communications·Tetsuya ToyamaTakeshi Okanoue
May 4, 2005·Cancer Research·Tatsuo ShimuraAvraham Raz
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Neil C HendersonTariq Sethi
Mar 25, 2006·The Journal of Clinical Investigation·Ke MaDavid D Moore
Apr 19, 2006·Journal of Hepatology·John Willy HaukelandPål Aukrust
Jun 27, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Anna WieckowskaAriel E Feldstein
Sep 21, 2006·American Journal of Physiology. Endocrinology and Metabolism·Shen QuH Henry Dong
Oct 3, 2006·Biochemical and Biophysical Research Communications·Caiyan ZhaoAnna Mae Diehl
Apr 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yasushi OgawaMakoto Kuro-o
Jul 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Puneet PuriArun J Sanyal
Apr 29, 2008·Molecular Cell·Dana M GwinnReuben J Shaw
Oct 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yan-Dong WangWendong Huang
Apr 11, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Carla IacobiniGiuseppe Pugliese
May 14, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amélie MoreauJean-Marc Pascussi
Jun 26, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Karlin Raja KarlmarkFrank Tacke
Nov 27, 2009·Pharmacogenetics and Genomics·Silvia SookoianCarlos Jose Pirola

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Citations

Oct 6, 2016·Expert Opinion on Drug Discovery·Thelma S Angeles, Robert L Hudkins
Feb 7, 2017·Expert Review of Gastroenterology & Hepatology·Jake P MannValerio Nobili
Dec 17, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Feng-Juan YanHongliang Li
Aug 16, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Giovanni MussoElena Paschetta
Mar 1, 2017·Journal of Lipid Research·Giovanni MussoRoberto Gambino
Jul 1, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Juan P ArabMichael Trauner
Dec 13, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·A DashB R Wamhoff
Nov 24, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giovanni MussoRoberto Gambino
Mar 1, 2017·BMC Medicine·Brent A Neuschwander-Tetri
Nov 22, 2017·Antioxidants & Redox Signaling·Naila Rabbani, Paul J Thornalley
Feb 17, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiao-Jing ZhangHongliang Li
Jan 31, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jun GongZhi-Gang She
Jan 20, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kristen T CrowellCharles H Lang
Aug 6, 2016·Scandinavian Journal of Immunology·Y-Y SunJ Li
May 31, 2018·Medicinal Research Reviews·Jingjing CaiHongliang Li
May 17, 2018·European Journal of Endocrinology·Adrian T BilleterBeat P Müller-Stich
Nov 24, 2019·Metabolites·Fabienne RajasGilles Mithieux
Apr 1, 2020·International Journal of Molecular Sciences·KyeongJin Kim, Kook Hwan Kim
May 13, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhanfang Kang, Rongrong Fan
Mar 8, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Xiaoya LiHai-Xin Yuan
Jul 29, 2020·The Journal of Pharmacology and Experimental Therapeutics·Mitsugi OokawaraYusuke Moritoh
Jun 28, 2020·Gut·Veera Raghavan ThangapandiPallavi Subramanian
Mar 4, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Hongshan LiYaoren Hu
Aug 5, 2017·BioMed Research International·Yu LiuMingli Peng

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