Abstract
Heparin has long been known to possess biological effects that are unrelated to its anticoagulant activity. In particular, much emphasis has been placed upon heparin, or novel agents based upon the heparin template, as potential anti-inflammatory agents. Moreover, heparin has been reported to possess clinical benefit in humans, including in chronic inflammatory diseases and cancer, that are over and above the expected effects on blood coagulation and which in many cases are entirely separable from this role. This chapter aims to provide an overview of the non-anticoagulant effects that have been ascribed to heparin, from those involving the binding and inhibition of specific mediators involved in the inflammatory process to effects in whole system models of disease, with reference to the effects of heparin that have been reported to date in human diseases.
Citations
Oct 3, 2012·American Journal of Respiratory and Critical Care Medicine·Elisabeth Bendstrup, Ole Hilberg
Aug 27, 2015·Expert Review of Clinical Pharmacology·Qi Ying LeanRahul P Patel
Oct 4, 2013·COPD·Yongbing QianRuilan Wang
May 23, 2015·Molecular Medicine Reports·Zhiyong LiuXiaochun Ma
Feb 23, 2013·Mediators of Inflammation·Tamilselvan SubramaniNoorjahan Banu Alitheen
Aug 29, 2013·ISRN Pharmacology·Clive Page
Apr 20, 2016·Journal of Comparative Effectiveness Research·Mandana IzadpanahMohammad Ali Faramarzi
Mar 11, 2017·Cutaneous and Ocular Toxicology·Liu Jian-WeiDeng Ai-Jun
May 5, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Erik G HaymanJ Marc Simard
Apr 2, 2017·Carbohydrate Polymers·Inga LiewertSusanne Alban
Mar 6, 2018·Vascular Medicine·Anthony N HageJeffrey Forris Beecham Chick
Jul 1, 2015·Journal of Neuro-oncology·Rosalie SchnoorMarike L D Broekman
Oct 8, 2014·Experimental and Therapeutic Medicine·Amal HassaninDalia Saleh
Jul 17, 2015·Blood·Kazuhisa MiyakawaRobert A Roth
Mar 10, 2020·The Analyst·Yunlong Zhao, Igor A Kaltashov
Dec 17, 2015·Pharmacological Reviews·Barbara MulloyClive P Page
Dec 17, 2014·American Journal of Reproductive Immunology : AJRI·Lydia LuleyAna C Zenclussen
Jan 4, 2018·Blood Advances·Amy K L ChuiJoanne M Said
Aug 14, 2019·Pharmaceutical Biology·QingShan YeXin Liu
Jan 15, 2019·Translational Vision Science & Technology·Joseph D BogaardIris S Kassem
May 30, 2020·PloS One·John HogwoodElaine Gray
Jan 20, 2015·Acta Anaesthesiologica Scandinavica·J A Kolsen-Petersen
May 3, 2018·Annals of Hematology·Alfonso VignoliAnna Falanga
Nov 1, 2020·Journal of Biomedical Materials Research. Part a·Sanja StojanovićStevo Najman
Aug 31, 2020·Clinical Medicine : Journal of the Royal College of Physicians of London·Carina ConzelmannAlexander Kleger
Feb 20, 2020·Seminars in Cancer Biology·Cristina FloreanMarc Diederich