Non-aqueous spray solvents and solubility effects in desorption electrospray ionization.

Journal of the American Society for Mass Spectrometry
Abraham Badu-TawiahR Graham Cooks

Abstract

The use of non-aqueous solvents in desorption electrospray ionization mass spectrometry (DESI-MS) is explored by analyzing a set of 43 compounds using binary mixtures of chloroform, tetrahydrofuran, and acetonitrile as the spray solvent. Comparisons of data obtained from chloroform/tetrahydrofuran (1:1) and chloroform/acetonitrile (1:1) spray solvents with the standard aqueous-based spray solvent (methanol/water, 1:1) shows that the non-aqueous systems have practical value for DESI, especially in the analysis of hydrophobic compounds. Non-aqueous spray solvents were used to ionize thermometer molecules (benzyl pyridinium salts) and showed lower internal energies (softer DESI ionization compared with methanol/water, 1:1), a result that has parallels in known solvent effects in electrospray ionization and is explained by solvent effects on surface tension. Consideration of octanol/water partition coefficients (K(ow)) of the 43 analytes in the light of their DESI results reveals the importance of the solubility of analyte in the spray solvent in producing high quality mass spectra. This finding provides additional support for the droplet pick-up description of the DESI mechanism, which is based on analyte dissolution in the spray ...Continue Reading

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Citations

Jul 27, 2011·Analytical and Bioanalytical Chemistry·Allison L DillR Graham Cooks
Jun 19, 2012·Analytical and Bioanalytical Chemistry·Dahlia I CampbellR Graham Cooks
Aug 22, 2012·Journal of the American Society for Mass Spectrometry·Kevin A DouglassAndre R Venter
May 21, 2010·Journal of the American Society for Mass Spectrometry·Abraham Badu-Tawiah, R Graham Cooks
Apr 19, 2011·Analytical Chemistry·Glenn A HarrisFacundo M Fernández
Jan 11, 2013·Chemical Reviews·María Eugenia MongeFacundo M Fernández
Feb 3, 2011·Chemical Communications : Chem Comm·Anyin LiR Graham Cooks
Feb 1, 2013·Molecular BioSystems·Pui-Kin SoZhong-Ping Yao
Jan 22, 2013·Annual Review of Physical Chemistry·Abraham K Badu-TawiahR Graham Cooks
Jul 12, 2014·Journal of the American Society for Mass Spectrometry·Paul M FlaniganRobert J Levis
Feb 24, 2016·Frontiers in Plant Science·Yonghui DongPietro Franceschi
Mar 19, 2013·Forensic Science International : Synergy·Marie MorelatoClaude Roux
Nov 4, 2011·Forensic Science International : Synergy·Marie MorelatoClaude Roux
Jul 5, 2011·Current Opinion in Chemical Biology·Ryan D EspyR Graham Cooks
Jul 28, 2011·Chembiochem : a European Journal of Chemical Biology·Livia S EberlinR Graham Cooks
Aug 18, 2012·Journal of Mass Spectrometry : JMS·Manel FriiaWilliam Buchmann
May 16, 2013·Journal of Mass Spectrometry : JMS·Kevin Aart Douglass, Andre R Venter
Mar 1, 2015·Journal of the American Society for Mass Spectrometry·Paul M FlaniganRobert J Levis
Jan 24, 2015·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Rick W FedeniukBryn Shurmer
Aug 27, 2016·Journal of the American Society for Mass Spectrometry·Si ChengHao Chen
Nov 5, 2014·Analytical Chemistry·Nicolas V SchwabDemian R Ifa
Sep 11, 2019·Journal of the American Society for Mass Spectrometry·Syed G T KazimiIan S Campbell
Sep 22, 2012·Mass Spectrometry Reviews·Chunping WuDemian R Ifa
Jul 28, 2020·Journal of Mass Spectrometry : JMS·Hyungjun KimSunghwan Kim
May 15, 2018·Analytica Chimica Acta·Sierra JacksonAbraham K Badu-Tawiah
Sep 11, 2019·Journal of the American Society for Mass Spectrometry·Anqi Tu, David C Muddiman
May 2, 2018·Journal of the American Society for Mass Spectrometry·Wanpeng AiHuwei Liu
Nov 2, 2019·Analytical Chemistry·Devin J SwinerAbraham K Badu-Tawiah
Oct 21, 2020·Journal of the American Society for Mass Spectrometry·Haidy MetwallyRichard Oleschuk

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