Non-B DNA structure-induced genetic instability

Mutation Research
Guliang Wang, Karen M Vasquez

Abstract

Repetitive DNA sequences are abundant in eukaryotic genomes, and many of these sequences have the potential to adopt non-B DNA conformations. Genes harboring non-B DNA structure-forming sequences increase the risk of genetic instability and thus are associated with human diseases. In this review, we discuss putative mechanisms responsible for genetic instability events occurring at these non-B DNA structures, with a focus on hairpins, left-handed Z-DNA, and intramolecular triplexes or H-DNA. Slippage and misalignment are the most common events leading to DNA structure-induced mutagenesis. However, a number of other mechanisms of genetic instability have been proposed based on the finding that these structures not only induce expansions and deletions, but can also induce DNA strand breaks and rearrangements. The available data implicate a variety of proteins, such as mismatch repair proteins, nucleotide excision repair proteins, topoisomerases, and structure specific-nucleases in the processing of these mutagenic DNA structures. The potential mechanisms of genetic instability induced by these structures and their contribution to human diseases are discussed.

References

Jan 1, 1992·Methods in Enzymology·B H Johnston
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B WittigA Rich
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·B J RaoC M Radding
May 1, 1991·The Biochemical Journal·P KrishnaJ H van de Sande
Jan 11, 1990·Nucleic Acids Research·J R SpitznerM T Muller
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A M FreundR P Fuchs
Jan 1, 1989·Genome Génome / Conseil National De Recherches Canada·S P MooreR Fishel
Jan 1, 1989·Progress in Nucleic Acid Research and Molecular Biology·J A Blaho, R D Wells
Apr 20, 1989·Journal of Molecular Biology·J C Lindsey, D R Leach
Sep 25, 1986·Nucleic Acids Research·K E Murphy, J R Stringer
Sep 30, 1988·Science·H Htun, J E Dahlberg
Jan 1, 1986·Cancer Genetics and Cytogenetics·B S EmanuelM A Israel
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·U Weiss, J H Wilson
Jan 1, 1981·Cold Spring Harbor Symposia on Quantitative Biology·J Collins
May 17, 1984·Nature·P Howard-FlandersA Stasiak
Aug 5, 1984·Nature·C LagravèreJ Laval
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·F WienerM Potter
Jan 1, 1982·Annual Review of Biochemistry·S B Zimmerman
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·A JaworskiR D Wells
Jun 11, 1995·Nucleic Acids Research·G P Schroth, P S Ho
Jan 1, 1993·Genes, Chromosomes & Cancer·P SeitéC J Larsen
Dec 1, 1994·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D R Leach
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·S M Rooney, P D Moore
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·B J Rao, C M Radding
Jun 3, 1994·Journal of Molecular Biology·V B ZhurkinR L Jernigan
Jan 14, 1994·Journal of Molecular Biology·S Lin, D Kowalski

❮ Previous
Next ❯

Citations

Sep 4, 2009·Cellular and Molecular Life Sciences : CMLS·Junhua ZhaoKaren M Vasquez
Feb 3, 2009·Journal of Molecular Evolution·Miguel A Varela, William Amos
Jun 30, 2009·European Biophysics Journal : EBJ·R S ConroyJ Moreland
May 29, 2009·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Jessica KolbHildegard Kehrer-Sawatzki
Aug 2, 2012·Quarterly Reviews of Biophysics·Jonathan M FoggLynn Zechiedrich
Dec 15, 2010·Biochemistry·Natalya N DegtyarevaJeffrey T Petty
Aug 27, 2013·Chemical Reviews·Boris P BelotserkovskiiPhilip C Hanawalt
Nov 22, 2008·Nature Reviews. Molecular Cell Biology·Philip C Hanawalt, Graciela Spivak
May 8, 2010·Chemical Communications : Chem Comm·Arivazhagan RajendranNaoki Sugimoto
Jul 18, 2008·Proceedings of the National Academy of Sciences of the United States of America·Irina VoineaguSergei M Mirkin
Nov 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jens VölkerKenneth J Breslauer
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Boris P BelotserkovskiiPhilip C Hanawalt
Feb 23, 2008·The Journal of Biological Chemistry·Silvia TornalettiPhilip C Hanawalt
Oct 30, 2008·The Journal of Biological Chemistry·Robert D Wells
Sep 10, 2011·AIDS Research and Human Retroviruses·Elisa De CrignisCecilia Graziosi
Mar 12, 2009·Nucleic Acids Research·Heng LiPeter Dröge
Aug 5, 2010·Nucleic Acids Research·David HerrmannRobert Wagner
Apr 19, 2011·Nucleic Acids Research·Mridula Nambiar, Sathees C Raghavan
Oct 11, 2011·Nucleic Acids Research·Ranjith P AnandCatherine H Freudenreich
Jul 3, 2013·Molekuliarnaia biologiia·B L ZybaĭlovV I Glazko
Mar 1, 2012·Cell & Bioscience·Guoqi Liu, Michael Leffak
Dec 25, 2012·Genome Biology·Margarida Cardoso-MoreiraAndrew G Clark
Oct 7, 2011·Journal of Nucleic Acids·Sudha Sharma
Jul 2, 2014·PloS One·Promita BoseM Katharine Rudd
Jan 9, 2013·Human Molecular Genetics·Laura W DillonYuh-Hwa Wang
Apr 24, 2013·The Journal of Cell Biology·Valérie BergoglioJean-Sébastien Hoffmann
Sep 1, 2014·Genomics·Jay C Brown
Dec 12, 2012·Mutation Research·Karen M Vasquez, Guliang Wang
Mar 30, 2010·Journal of Molecular Biology·Diem T KhaKaren M Vasquez
Mar 5, 2016·The Journal of Physical Chemistry. B·Hugo GattusoAntonio Monari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Guliang Wang, Karen M Vasquez
Proceedings of the National Academy of Sciences of the United States of America
A BacollaR D Wells
Proceedings of the National Academy of Sciences of the United States of America
Guliang WangKaren M Vasquez
© 2021 Meta ULC. All rights reserved