Non-Brownian diffusion of membrane molecules in nanopatterned supported lipid bilayers.

Nano Letters
Jones TsaiL Kam

Abstract

Molecules associated with the outer surface of living cells exhibit complex, non-Brownian patterns of diffusion. In this report, supported lipid bilayers were patterned with nanoscale barriers to capture key aspects of this anomalous diffusion in a controllable format. First, long-range diffusion coefficients of membrane-associated molecules were significantly reduced by the presence of the barriers, while short-range diffusion was unaffected. Second, this modulation was more pronounced for large molecular complexes than for individual lipids. Surprisingly, the quantitative effect of these barriers on long-range lipid diffusion could be accurately simulated using a simple, continuum-based model of diffusion on a nanostructured surface; we thus describe a metamaterial that captures the properties of the outer membrane of living cells.

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·B A SmithH M McConnell
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A A Brian, H M McConnell
Feb 1, 1994·Protein Science : a Publication of the Protein Society·E A MerrittW G Hol
Aug 1, 1996·Current Opinion in Cell Biology·A Kusumi, Y Sako
Jan 31, 1997·Science·J T GrovesS G Boxer
Oct 6, 1999·Current Opinion in Cell Biology·A KusumiK Koyasako
Dec 5, 2000·Current Opinion in Chemical Biology·S G Boxer
Mar 20, 2002·Accounts of Chemical Research·Jay T Groves, Steven G Boxer
Jun 12, 2002·The Journal of Cell Biology·Takahiro FujiwaraAkihiro Kusumi
Jul 3, 2003·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Hiroshi IkeAkihiro Kusumi
Jul 9, 2004·Biophysical Journal·Frank Y JiangJames T Kindt
Oct 28, 2004·Journal of the American Chemical Society·Chanel K YeeAtul N Parikh
May 5, 2005·Journal of the American Chemical Society·Michael C HowlandAtul N Parikh
Nov 19, 2005·Science·Kaspar D MossmanMichael L Dustin
Feb 10, 2007·Journal of the American Chemical Society·Andreia M SmithAtul N Parikh
Jul 26, 2008·Nature Nanotechnology·Xinjian ZhouPaul L McEuen

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Citations

Dec 7, 2011·Annals of Biomedical Engineering·Christopher V Kelly, Harold G Craighead
Aug 28, 2009·Journal of the American Chemical Society·Keyue ShenLance C Kam
Sep 16, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Mari-Liis VisnapuuEric C Greene
Jul 19, 2013·Annual Review of Biomedical Engineering·L C KamM L Dustin
Jan 1, 2009·Materials Research Society Symposia Proceedings·Keyue ShenLance C Kam
Aug 2, 2015·Chemistry and Physics of Lipids·C Patrick Collier
Aug 29, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Michael C Milone, Lance C Kam
Jun 24, 2008·Biophysical Journal·Peter JönssonFredrik Höök
Dec 25, 2012·Biophysical Journal·Michael J Saxton
Nov 10, 2012·Analytical Chemistry·Peng BaoStephen D Evans
Apr 7, 2010·Cellular and Molecular Bioengineering·J Tsai, L C Kam
Mar 30, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Alexander JohnsonGraham J Leggett

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