Non-calorimetric determination of absorbed power during magnetic nanoparticle based hyperthermia

Scientific Reports
I GresitsF Simon

Abstract

Nanomagnetic hyperthermia (NMH) is intensively studied with the prospect of cancer therapy. A major challenge is to determine the dissipated power during in vivo conditions and conventional methods are either invasive or inaccurate. We present a non-calorimetric method which yields the heat absorbed during hyperthermia: it is based on accurately measuring the quality factor change of a resonant radio frequency circuit which is employed for the irradiation. The approach provides the absorbed power in real-time, without the need to monitor the sample temperature as a function of time. As such, it is free from the problems caused by the non-adiabatic heating conditions of the usual calorimetry. We validate the method by comparing the dissipated power with a conventional calorimetric measurement. We present the validation for two types of resonators with very different filling factors: a solenoid and a so-called birdcage coil. The latter is a volume coil, which is generally used in magnetic resonance imaging (MRI) under in vivo condition. The presented method therefore allows to effectively combine MRI and thermotherapy and is thus readily adaptable to existing imaging hardware.

References

May 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M D Harpen
Mar 7, 2001·Physics in Medicine and Biology·T S IbrahimP M Robitaille
Oct 12, 2010·IEEE Transactions on Magnetics·Kannan M Krishnan
Mar 31, 2011·Advanced Drug Delivery Reviews·Challa S S R Kumar, Faruq Mohammad
Mar 1, 2010·Nano LIFE·Andrew J GiustiniP Jack Hoopes
Dec 20, 2015·IEEE Transactions on Bio-medical Engineering·Elena LucanoLeonardo M Angelone
Jun 7, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaber BeikS Kamran Kamrava
Feb 22, 2017·Biochimica Et Biophysica Acta. General Subjects·M Angelakeris

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Citations

Sep 7, 2019·Nanotechnology·Kai WuJian-Ping Wang
Mar 3, 2021·Journal of Nanobiotechnology·Shan ZhaoZi Chen

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Methods Mentioned

BETA
chip
irradiating

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