Non-cAMP-mediated bronchial arterial vasodilation in response to inhaled beta-agonists

Journal of Applied Physiology
P CarvalhoN B Charan

Abstract

We studied the dose-dependent effects of inhaled isoetharine HCl, a beta-adrenergic bronchodilator (2.5, 5.0, 10.0, and 20.0 mg), on bronchial blood flow (Qbr) in anesthetized sheep. Isoetharine resulted in a dose-dependent increase in Qbr. With a total dose of 17.5 mg, Qbr increased from baseline values of 22 +/- 3.4 (SE) to 60 +/- 16 ml/min (P < 0.001), an effect independent of changes in cardiac output and systemic arterial pressure. To further study whether synthesis of endogenous nitric oxide (NO) affects beta-agonist-induced increases in Qbr, we administered isoetharine (20 mg) by inhalation before and after the NO-synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME). Intravenous L-NAME (30 mg/kg) rapidly decreased Qbr by approximately 80% of baseline, whereas L-NAME via inhalation (10 mg/kg) resulted in a delayed and smaller (approximately 22%) decrease. Pretreatment with L-NAME via both routes of administration attenuated bronchial arterial vasodilation after subsequent challenge with isoetharine. We conclude that isoetharine via inhalation increases Qbr in a dose-dependent manner and that beta-agonist-induced relaxation of vascular smooth muscle in the bronchial vasculature is partially mediated via synthe...Continue Reading

References

Aug 1, 1988·Journal of Applied Physiology·J A BarkerA Wanner
Jul 1, 1988·Journal of Applied Physiology·A WannerA D Chediak
Dec 1, 1987·British Journal of Pharmacology·L A LaitinenJ G Widdicombe
Aug 1, 1985·Journal of Applied Physiology·N B CharanR Ripley
Aug 3, 1984·European Journal of Pharmacology·J R CarstairsP J Barnes
Sep 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·N B CharanR Dhand
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Feb 1, 1994·The Journal of Clinical Investigation·T ImaiF Marumo
May 1, 1994·British Journal of Pharmacology·H MühlJ Pfeilschifter
Feb 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·T M Lincoln, T L Cornwell
Dec 21, 1993·European Journal of Pharmacology·Y X WangC C Pang
Mar 1, 1996·American Journal of Respiratory and Critical Care Medicine·M R CorbozA E Taylor
Feb 1, 1997·Journal of Applied Physiology·N B CharanP Carvalho

❮ Previous
Next ❯

Citations

Sep 14, 1999·Journal of Applied Physiology·M A NørgaardG Pettersson
Aug 17, 2010·American Journal of Respiratory and Critical Care Medicine·Adam Wanner, Eliana S Mendes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.