Non-cardiac Chest Pain and Anxiety: A Possible Link to Vitamin D and Calcium

Journal of Clinical Psychology in Medical Settings
Mohammad J AlkhatatbehMohamad Al-Jarrah

Abstract

This study was performed to check the hypothesis that low serum vitamin D and reduced calcium intake may contribute to the comorbidity of psychological symptoms (anxiety and depression) and non-cardiac chest pain (NCCP). The design was a case-control study that involved 40 subjects with NCCP and 40 age and gender-matched healthy controls. Serum vitamin D was assessed using electrochemiluminescence immunoassay; anxiety and depression symptoms were assessed using Hospital Anxiety and Depression Scale, and dietary calcium intake was assessed by self-reporting. Subjects with NCCP had higher anxiety and depression scores and lower vitamin D and dietary calcium intake compared to healthy controls (p < .05). NCCP was associated with anxiety score (odds ratio = 1.40, p < .01). Prevalence of abnormal anxiety score was much higher in subjects with NCCP (47.5%) compared to healthy controls (7.5%). Anxiety score was inversely correlated with vitamin D level and dietary calcium intake (p < .01). Anxiety score was inversely associated with vitamin D level (R2 = .32, p < .05). In conclusion, development of NCCP can be predicted from increased anxiety score which in turn can be predicted from low vitamin D levels. This suggests physicians to c...Continue Reading

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Citations

Mar 15, 2019·Neurourology and Urodynamics·Khalid K Abdul-RazzakFeras E Sahawneh
Nov 24, 2019·International Journal of Environmental Research and Public Health·Michael DoulberisDavid Shiva Srivastava
May 20, 2020·Perspectives in Psychiatric Care·Mohammad J AlkhatatbehHala N Khwaileh
May 30, 2021·International Journal of Clinical Practice·Abdallah Y NaserEmad M Salawati

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