Non-cardioembolic risk factors in atrial fibrillation-associated ischemic stroke

PloS One
Pil-Sung YangJi Hoe Heo

Abstract

Cardioembolic (CE) risks is usually considered as the main mechanism of ischemic stroke in non-valvular atrial fibrillation (NVAF) patients. However, a substantial number of ischemic strokes in NVAF patients are related to non-CE mechanisms. The aim of this study was to investigate the non-CE risk factors in ischemic stroke patients had NVAF. We included 401 patients (65.6% male, 68.6 ± 9.6 years old) who had been hospitalized due to ischemic stroke and had a known or newly diagnosed NVAF. The CE (intracardiac thrombus, dense spontaneous echo contrast, or low left atrial appendage flow velocity) and non-CE (complex aortic plaque, significant carotid stenosis, or intracranial arterial stenosis) risk factors were investigated at the time of the index stroke. The number of CE and non-CE risk factors increased with increasing CHA2DS2-VASc scores (p for trends < 0.001). The presence of CE risk factors was independently associated with persistent atrial fibrillation (p < 0.001), body mass index (p = 0.003), heart failure (p = 0.003), and left atrial volume index (p < 0.001). In contrast, the presence of non-CE risk factors was independently associated with age (p < 0.001), hypertension (p = 0.049), diabetes (p = 0.030), and coronary ...Continue Reading

References

Dec 10, 1999·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·M E GoldmanJ L Halperin
Jan 26, 2002·Cerebrovascular Diseases·Yeu-Jhy ChangShinn-Kuang Lin
Mar 17, 2007·Stroke; a Journal of Cerebral Circulation·Bertine M B GoessensYolanda van der Graaf
Oct 7, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M-J ChaJ H Heo
Nov 15, 2011·The New England Journal of Medicine·Jessica L MegaUNKNOWN ATLAS ACS 2–TIMI 51 Investigators
Jul 28, 2012·The Journal of Pharmacology and Experimental Therapeutics·Illkyu-O LeeMichael Böhm
Mar 2, 2013·Stroke; a Journal of Cerebral Circulation·Dirk M HermannUNKNOWN Heinz Nixdorf Recall Study Investigative Group
Oct 19, 2013·Lancet Neurology·Christine A HolmstedtMarc I Chimowitz
May 3, 2014·Stroke; a Journal of Cerebral Circulation·Walter N KernanUNKNOWN American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, and
Oct 31, 2014·Stroke; a Journal of Cerebral Circulation·James F MeschiaUNKNOWN Council on Hypertension
Mar 3, 2015·Journal of Cardiovascular Electrophysiology·Maxime Tremblay-GravelPaul Khairy
May 6, 2015·JACC. Cardiovascular Imaging·Harvey S Hecht
Mar 5, 2016·Neurology·Rainer MalikUNKNOWN NINDS Stroke Genetics Network (SiGN)
Apr 26, 2016·Cerebrovascular Diseases·Asako NakamuraUNKNOWN Fukuoka Stroke Registry Investigators
Nov 4, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Paulus KirchhofKatja Zeppenfeld

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Citations

Apr 8, 2020·Stroke; a Journal of Cerebral Circulation·Shaan KhurshidSteven A Lubitz
Apr 30, 2020·AJR. American Journal of Roentgenology·Dustin HillersonSteve W Leung
Jul 29, 2019·Current Cardiology Reports·Pooja S Jagadish, Rajesh Kabra
Nov 30, 2019·Current Atherosclerosis Reports·Zhaojia WangTong Liu
Oct 2, 2020·The American Journal of Medicine·Alexander OmelchenkoDavid Pereg
Jun 3, 2021·Journal of Clinical Medicine·So-Ryoung LeeGregory Y H Lip

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