Non-catch-up growth in intrauterine growth-retarded rats showed glucose intolerance and increased expression of PDX-1 mRNA

Pediatrics International : Official Journal of the Japan Pediatric Society
Jung Sub LimSei Won Yang

Abstract

Children born with intrauterine growth retardation (IUGR) show long-term complications like non-catch-up growth and type 2 diabetes. We hypothesize that the duration of malnutrition influences the growth and pancreatic development in IUGR. The pancreatic duodenal homeobox-1 (PDX-1) expression might also be different because it links glucose metabolism to the regulation of insulin gene transcription in the pancreas. We made an IUGR rat model with a low-protein diet (8% casein) during gestational periods. Catch-up rats (CU) were given normal lab chow immediately after birth. Non-catch-up rats (NCU) were given normal lab chow after lactation periods. PDX-1 mRNA level, islet areas and intravenous glucose tolerance test (IVGTT) were assessed in each group and compared with control rats (C) at the 16th week. The weight and length of CU and C rats were not different after 3 weeks, while NCU rats were smaller than C and CU rats (P < 0.05). In IVGTT, the 20-min and 50-min glucose level and area under the curve for glucose were increased in NCU rats compared with those values in C and CU rats (P < 0.05). The islet area of NCU rats was smaller than that of C and CU rats (P < 0.05). In contrast, PDX-1 mRNA levels of NCU rats were higher th...Continue Reading

References

May 1, 1992·Diabetologia·S RobinsonC Osmond
Oct 26, 1991·BMJ : British Medical Journal·C N HalesP D Winter
Jul 1, 1995·The Proceedings of the Nutrition Society·S DahriJ J Hoet
May 1, 1996·Biochemical Society Transactions·C N HalesN J Crowther
Feb 5, 1998·Lancet·A C RavelliO P Bleker
Nov 5, 1999·The Journal of Clinical Investigation·W M MacfarlaneA T Hattersley
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·D JaquetC Levy-Marchal
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·M H VickersP D Gluckman
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 9, 2002·International Journal of Experimental Diabetes Research·C J PetryC N Hales
May 20, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·C A NewsomeC M Law
May 6, 2004·Annals of the New York Academy of Sciences·Hyeong Kyu ParkHong Kyu Lee
Mar 1, 2005·Diabetes·Silvia Del GuerraPiero Marchetti

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Citations

May 23, 2014·Journal of Developmental Origins of Health and Disease·J-S WattezD Vieau
Sep 3, 2014·The Journal of Clinical Investigation·Emilyn U AlejandroErnesto Bernal-Mizrachi
Aug 16, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ramkumar MohanEmilyn Uy Alejandro
Jun 17, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Máté DurstZsuzsanna E Tóth
Apr 17, 2014·American Journal of Physiology. Endocrinology and Metabolism·Marianna SadagurskiRichard A Miller

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