Non-cell-autonomous actions of α-synuclein: Implications in glial synucleinopathies

Progress in Neurobiology
Somin LimSeung-Jae Lee

Abstract

Many neurodegenerative diseases are derived from the combined consequences of genetic and environmental factors. One of the common features implicated in the neurodegenerative processes is aggregation of disease-specific neuronal proteins. These proteins are accumulated not only directly in neurons, but also indirectly involve glial cells. Whereas the focus of research has been directed towards the impacts of protein aggregation upon neurons, the influence that it exerts on glial cells has been relatively overlooked. Recent studies, however, provide strong evidence on pathogenic responses of glial cells originated from the neuron-derived protein aggregates. Here, we critically examine the latest advancement in investigating how glial cells are activated in neurodegenerative disorders that are associated with α-synuclein aggregates. Often referred to as synucleinopathies, these include Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. To further illustrate, we would discuss paracrine actions of α-synuclein aggregates secreted from neuronal cells in promoting pathogenic reactions from various types of glia and evaluate the non-cell-autonomous mechanism compared to a cell-autonomous one. Such analyses of t...Continue Reading

Citations

Jun 12, 2019·Oxidative Medicine and Cellular Longevity·Yang FengYunyou Duan
Aug 23, 2020·Biomolecules·Carl Alexander SandhofCarmen Nussbaum-Krammer
Sep 26, 2019·Neural Regeneration Research·Rachel KeryGregory W Kirschen
Jul 7, 2020·Frontiers in Neuroscience·Darren M O'HaraLorraine V Kalia
Jun 13, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Liuna YangJialong Chen
Oct 16, 2020·Science Translational Medicine·Changyoun KimEliezer Masliah
Jun 15, 2021·Frontiers in Neurology·Adina N MacMahon CopasMaeve A Caldwell

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