Non-cell autonomous and non-catalytic activities of ATX in the developing brain

Frontiers in Neuroscience
Raanan GreenmanOrly Reiner

Abstract

The intricate formation of the cerebral cortex requires a well-coordinated series of events, which are regulated at the level of cell-autonomous and non-cell autonomous mechanisms. Whereas cell-autonomous mechanisms that regulate cortical development are well-studied, the non-cell autonomous mechanisms remain poorly understood. A non-biased screen allowed us to identify Autotaxin (ATX) as a non-cell autonomous regulator of neural stem cells. ATX (also known as ENPP2) is best known to catalyze lysophosphatidic acid (LPA) production. Our results demonstrate that ATX affects the localization and adhesion of neuronal progenitors in a cell autonomous and non-cell autonomous manner, and strikingly, this activity is independent from its catalytic activity in producing LPA.

References

May 29, 1992·Biochemical and Biophysical Research Communications·Y YoshiharaY Watanabe
Aug 1, 1973·Virology·F L Graham, A J van der Eb
Sep 26, 2000·Human Molecular Genetics·M CaspiO Reiner
Nov 1, 2000·Nature Cell Biology·N E FaulknerR B Vallee
Jul 12, 2002·Journal of Neural Transmission·O V ForlenzaW F Gattaz
Apr 15, 2003·Nature Structural Biology·Myung Hee KimZygmunt S Derewenda
Oct 11, 2003·Mechanisms of Development·Miki TsukadaGregor Eichele
Nov 19, 2003·Journal of Neurochemistry·Yuko FujiwaraGabor Tigyi
Nov 20, 2003·Nature Neuroscience·Jilin BaiJoseph J LoTurco
Nov 20, 2003·Nature Neuroscience·Marcy A KingsburyJerold Chun
Feb 7, 2004·The EMBO Journal·Amos GdalyahuOrly Reiner
Jun 15, 2004·Nature Medicine·Makoto InoueHiroshi Ueda
Jul 20, 2004·Journal of Cellular Biochemistry·Nobuyuki Fukushima
Jul 29, 2004·FEBS Letters·Masayuki TanakaHiroyuki Arai
Oct 16, 2004·Molecular and Cellular Neurosciences·Michael A FoxBabette Fuss
May 14, 2005·Developmental Biology·Natalia AbramovaSally Temple
Aug 30, 2005·Trends in Biochemical Sciences·Cristiana StefanMathieu Bollen
Mar 15, 2006·Neuroscience Letters·Ken UmemuraHideo Kimura
Mar 28, 2006·Biochemical and Biophysical Research Communications·Miki TsukadaGregor Eichele
Jun 20, 2006·Molecular and Cellular Biology·Laurens A van MeeterenJos Jonkers
Jul 11, 2006·The Journal of Biological Chemistry·Masayuki TanakaHiroyuki Arai
Aug 8, 2006·Nature Neuroscience·Silvia CappelloMagdalena Götz
Dec 29, 2006·Cellular and Molecular Life Sciences : CMLS·N E SavaskanA U Bräuer
Jan 16, 2007·Cell·Ramsés AyalaLi-Huei Tsai
Feb 20, 2007·The Journal of Biological Chemistry·Silvia JansenMathieu Bollen
Mar 17, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Hideyo OhuchiSumihare Noji
Jul 5, 2007·Genesis : the Journal of Genetics and Development·Diana Escalante-AlcaldeColin L Stewart
Jul 28, 2007·Cerebral Cortex·Guillermo Estivill-TorrúsFernando Rodríguez De Fonseca
Aug 19, 2007·Journal of Proteome Research·Mauro D ZappaterraBryan A Ballif

❮ Previous
Next ❯

Citations

Dec 24, 2016·Cell Reports·Ingrid EhrmannDavid J Elliott
Jun 29, 2018·Frontiers in Medicine·Ioanna NinouVassilis Aidinis
Jul 4, 2017·Frontiers in Cellular Neuroscience·Anna GorelikOrly Reiner
Oct 24, 2020·The Journal of Biological Chemistry·Xin XuXiaotian Zhang
Sep 1, 2019·Journal of Autoimmunity·Christiana MagkriotiVassilis Aidinis
Feb 3, 2021·Signal Transduction and Targeted Therapy·Luiz Henrique Medeiros GeraldoFlavia Regina Souza Lima
Feb 1, 2020·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Seung-Jae KimGye Young Park
Jan 18, 2021·The Journal of Biological Chemistry·Xin XuXiaotian Zhang

❮ Previous
Next ❯

Methods Mentioned

BETA
GTPases
glycosylation
transgenic
PCR
flow cytometry
transfection
confocal microscopy
chip
electron microscopy
dissection

Software Mentioned

Imaris
Imaris©
DeltaVision
GraphPad
Affymetrix
Prism
ImageJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved