Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g

Cerebral Cortex
Jessica ApuleiAlain Prochiantz

Abstract

The non-cell autonomous transfer of OTX2 homeoprotein transcription factor into juvenile mouse cerebral cortex regulates parvalbumin interneuron maturation and critical period timing. By analyzing gene expression in primary visual cortex of wild-type and Otx2+/GFP mice at plastic and nonplastic ages, we identified several putative genes implicated in Otx2-dependent visual cortex plasticity for ocular dominance. Cortical OTX2 infusion in juvenile mice induced Gadd45b/g expression through direct regulation of transcription. Intriguingly, a reverse effect was found in the adult, where reducing cortical OTX2 resulted in Gadd45b/g upregulation. Viral expression of Gadd45b in adult visual cortex directly induced ocular dominance plasticity with concomitant changes in MeCP2 foci within parvalbumin interneurons and in methylation states of several plasticity gene promoters, suggesting epigenetic regulation. This interaction provides a molecular mechanism for OTX2 to trigger critical period plasticity yet suppress adult plasticity.

References

Oct 3, 1999·Nature Genetics·M C HollanderA J Fornace
Oct 2, 2002·Results and Problems in Cell Differentiation·Katrin I Andreasson, Walter E Kaufmann
Nov 9, 2002·Bioinformatics·Long-Cheng Li, Rajvir Dahiya
May 27, 2003·Neuron·Valery A Kalatsky, Michael P Stryker
Dec 8, 2005·Visual Neuroscience·Jianhua CangMichael P Stryker
Apr 4, 2006·Nature Neuroscience·Marta Majdan, Carla J Shatz
Apr 12, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gilles ChatelainThomas Lamonerie
Apr 25, 2006·Lancet·Jonathan M Holmes, Michael P Clarke
Apr 3, 2007·Molecular and Cellular Neurosciences·Ariel A Di NardoMaria Luz Montesinos
May 20, 2008·Nucleic Acids Research·Yuichi KumakiMasaki Okano
Oct 10, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Masaaki Sato, Michael P Stryker
Mar 6, 2009·Genome Biology·Ben LangmeadSteven L Salzberg
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Jun 24, 2009·Current Opinion in Neurobiology·Michela FagioliniFrances A Champagne
Oct 29, 2010·Genome Biology·Simon Anders, Wolfgang Huber
Feb 1, 2011·Nature Neuroscience·Jason D Shepherd, Mark F Bear
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Astrid VallèsPeter de Weerd
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David P GavinAlessandro Guidotti
Jan 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Adam RansonFrank Sengpiel
Feb 22, 2012·Trends in Cell Biology·Christof Niehrs, Andrea Schäfer
Mar 8, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arjun V SharmaClayton T Dickson
Apr 12, 2012·Bioinformatics·Laurent JourdrenStéphane Le Crom
May 1, 2012·Neuron·Daniëlle van VersendaalChristiaan N Levelt
Jul 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marine BeurdeleyAlain Prochiantz
Jul 18, 2012·Learning & Memory·Prescott T LeachThomas J Gould
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Faraz A SultanJ David Sweatt
Jun 19, 2013·Cell Reports·Julien SpatazzaAlain Prochiantz
Aug 13, 2013·Neural Plasticity·Ettore TiraboschiEero Castrén
Aug 27, 2013·Nature·Sandra J KuhlmanJoshua T Trachtenberg
Oct 8, 2013·Nature·Hyun-Jae PiAdam Kepecs
Dec 7, 2013·Progress in Brain Research·Anne E Takesian, Takao K Hensch
Feb 22, 2014·PloS One·Alexander SamuelThomas Lamonerie
Mar 19, 2014·Cell·Yu FuMichael P Stryker
Jul 1, 2014·Journal of Neurochemistry·Giulio Srubek TomassyMaurizio Giustetto

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Citations

Jun 7, 2020·Proceedings of the National Academy of Sciences of the United States of America·Rebecca K RehTakao K Hensch
Aug 2, 2018·Physiological Reviews·Ariel A Di NardoAlain Prochiantz
Oct 1, 2019·Neural Plasticity·Adema Ribic, Thomas Biederer
Oct 8, 2020·EMBO Reports·Debora NapoliTommaso Pizzorusso
Dec 3, 2020·Cellular and Molecular Life Sciences : CMLS·Britt MossinkNael Nadif Kasri
Jul 18, 2019·Cell Reports·Eun Jung LeeJin Woo Kim
Oct 30, 2020·Science Advances·Ariel A Di NardoAlain Prochiantz
Feb 16, 2021·Brain Structure & Function·John H HarknessBarbara A Sorg
Mar 7, 2021·International Journal of Molecular Sciences·Daniela Carulli, Joost Verhaagen
May 9, 2021·Molecular Psychiatry·Clémentine VincentAriel A Di Nardo
Aug 28, 2021·International Journal of Molecular Sciences·Anabelle PlanquesAriel A Di Nardo

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