Non-cell-autonomous OTX2 transcription factor regulates anxiety-related behavior in the mouse.

Molecular Psychiatry
Clémentine VincentAriel A Di Nardo

Abstract

The OTX2 homeoprotein transcription factor is expressed in the dopaminergic neurons of the ventral tegmental area, which projects to limbic structures controlling complex behaviors. OTX2 is also produced in choroid plexus epithelium, from which it is secreted into cerebrospinal fluid and transferred to limbic structure parvalbumin interneurons. Previously, adult male mice subjected to early-life stress were found susceptible to anxiety-like behaviors, with accompanying OTX2 expression changes in ventral tegmental area or choroid plexus. Here, we investigated the consequences of reduced OTX2 levels in Otx2 heterozygote mice, as well as in Otx2+/AA and scFvOtx2tg/0 mouse models for decreasing OTX2 transfer from choroid plexus to parvalbumin interneurons. Both male and female adult mice show anxiolysis-like phenotypes in all three models. In Otx2 heterozygote mice, we observed no changes in dopaminergic neuron numbers and morphology in ventral tegmental area, nor in their metabolic output and projections to target structures. However, we found reduced expression of parvalbumin in medial prefrontal cortex, which could be rescued in part by adult overexpression of Otx2 specifically in choroid plexus, resulting in increased anxiety-l...Continue Reading

References

Oct 23, 2003·Nature Reviews. Molecular Cell Biology·Alain Prochiantz, Alain Joliot
Jun 2, 2007·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Sarven SabunciyanSerge Weis
May 30, 2009·Proceedings of the National Academy of Sciences of the United States of America·Peter J UhlhaasEugenio Rodriguez
Nov 20, 2009·The International Journal of Developmental Biology·Michela Di SalvioAntonio Simeone
Apr 30, 2011·Neuroscience and Biobehavioral Reviews·David A Sturman, Bita Moghaddam
May 12, 2011·Development·Sophie LayalleFlorence Maschat
Jan 17, 2012·Nature Neuroscience·Shinji MiyataHiroshi Kitagawa
Jul 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Marine BeurdeleyAlain Prochiantz
Jun 19, 2013·Cell Reports·Julien SpatazzaAlain Prochiantz
Jul 3, 2013·Science·Maiken Nedergaard
Nov 16, 2013·Human Molecular Genetics·Clémence BernardJin Woo Kim
May 6, 2014·Frontiers in Human Neuroscience·Cortney A TurnerStanley J Watson
Nov 18, 2014·Nature Neuroscience·Andreas Lüthi, Christian Lüscher
Jan 15, 2015·Trends in Neurosciences·Ekaterina Likhtik, Rony Paz
Jan 28, 2015·Molecular Psychiatry·J A BrownKároly Mirnics
Mar 6, 2015·Neuron·Alain Prochiantz, Ariel A Di Nardo
May 21, 2015·Nature Reviews. Neuroscience·Philip TovoteAndreas Lüthi
Feb 13, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John F EnwrightDavid A Lewis
Jan 6, 2017·Nature Reviews. Neuroscience·Marisela Morales, Elyssa B Margolis
May 18, 2018·Cerebral Cortex·Jessica ApuleiAlain Prochiantz
Aug 2, 2018·Physiological Reviews·Ariel A Di NardoAlain Prochiantz
Aug 10, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joan KaufmanJames Hudziak
Jul 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Andrea M SantangeloAngela C Roberts
Jul 18, 2019·Cell Reports·Eun Jung LeeJin Woo Kim
Nov 16, 2019·International Journal of Bipolar Disorders·Julia AlcaideJuan Nacher
Feb 13, 2020·Developmental Cell·Ryann M Fame, Maria K Lehtinen
Mar 14, 2020·Pharmacology & Therapeutics·Andrea Carlo RossettiRaffaella Molteni
Apr 23, 2020·Frontiers in Behavioral Neuroscience·Ramon GuiradoEsther Castillo-Gómez

❮ Previous
Next ❯

Citations

Aug 28, 2021·International Journal of Molecular Sciences·Anabelle PlanquesAriel A Di Nardo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

BioRxiv : the Preprint Server for Biology
Clémentine VincentAlain Prochiantz
International Journal of Molecular Sciences
Anabelle PlanquesAriel A Di Nardo
BioRxiv : the Preprint Server for Biology
Anabelle PlanquesAriel A Di Nardo
BioRxiv : the Preprint Server for Biology
Anabelle PlanquesAriel A Di Nardo
© 2021 Meta ULC. All rights reserved