Non-Chlamydial Bacterial Infection and Progression of Conjunctival Scarring in Trachoma.

Investigative Ophthalmology & Visual Science
Victor H HuMatthew J Burton

Abstract

The purpose of this study was to assess whether non-chlamydial bacterial infection is associated with progression of trachomatous scarring in adults. This was a cohort study involving 800 participants in northern Tanzania who underwent clinical examination, photography, and conjunctival swab collection for microbiology over a 24-month period. Samples for microbiology were inoculated onto blood and chocolate agar, and Chlamydia trachomatis was detected by PCR. Progression was determined by comparison of baseline to 24-month photographs. C. trachomatis was detected in only four participants at baseline. At 24 months, 617 participants (77.1%) were followed up. Of those seen at 24 months, 452 could be reliably assessed. Definite scarring progression (progressors) was seen in 345 (55.9%); there was no progression (nonprogressors) in 107 (17.3%). Using combined baseline and 12-month microbiology results, progressors had significantly higher levels of commensal and pathogenic bacterial organisms detected compared with nonprogressors. After adjusting for age, baseline scarring, and ethnicity, there was weak evidence (P = 0.07) that the bacteria category was associated with scarring progression (commensal organisms only: odds ratio [OR]...Continue Reading

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Sep 17, 2011·Ophthalmology·Victor H HuMatthew J Burton
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Oct 27, 2016·PLoS Neglected Tropical Diseases·Athumani M RamadhaniMatthew J Burton
Jul 1, 2017·Investigative Ophthalmology & Visual Science·Jacob T CoxSheila K West

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Citations

Aug 15, 2019·PLoS Neglected Tropical Diseases·Athumani M RamadhaniMatthew J Burton
Aug 17, 2020·Clinical & Experimental Ophthalmology·Jeremy J HoffmanVictor H Hu
Sep 26, 2019·Frontiers in Cellular and Infection Microbiology·Harry PickeringMartin J Holland
Sep 7, 2019·Translational Vision Science & Technology·Sandra Liliana TaleroSheila K West
Oct 10, 2020·The Journal of Infectious Diseases·Harry PickeringScott D Nash

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