Non-Cochrane vs. Cochrane reviews were twice as likely to have positive conclusion statements: cross-sectional study

Journal of Clinical Epidemiology
Andrea C TriccoDavid Moher

Abstract

To determine which factors predict favorable results and positive conclusions in systematic reviews (SRs) and to assess the level of agreement between SR results and conclusions. A sample of 296 English SRs indexed in MEDLINE (November, 2004) was obtained. Two investigators independently categorized SR characteristics, results, and conclusions. Descriptive analyses and logistic regression predicting favorable results (nonstatistically significant and statistically significant positive) and positive conclusions were conducted. The level of concordance between results and conclusions was assessed using a weighted-kappa statistic. Overall, 36.5% of the SRs had favorable results, increasing to 57.7% for Cochrane and 64.3% for non-Cochrane reviews with a meta-analysis of the primary outcome. Non-Cochrane reviews with a meta-analysis of the primary outcome were twice as likely to have positive conclusions as Cochrane reviews with such an analysis (P-value<0.05). The weighted kappa for agreement between SR results and conclusions was 0.55. It was lower for Cochrane (0.41) vs. non-Cochrane (0.67) reviews. SRs including a meta-analysis of the primary outcome may be affected by indirect publication bias in our sample. Differences between...Continue Reading

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Citations

Jul 29, 2009·Current Psychiatry Reports·Jonathan C Ipser, Dan J Stein
Apr 1, 2011·BMC Medicine·Andrea C TriccoDavid Moher
Jun 3, 2014·BMC Pediatrics·Michele P HammLisa Hartling
Apr 17, 2014·Medicina clínica·Xavier Bonfill, UNKNOWN Centro Cochrane Iberoamericano
Jul 23, 2013·Mayo Clinic Proceedings·John P A Ioannidis
Oct 17, 2012·Physical Therapy in Sport : Official Journal of the Association of Chartered Physiotherapists in Sports Medicine·Ryan LobbLeica S Claydon
Nov 1, 2011·Studies in History and Philosophy of Biological and Biomedical Sciences·Jacob Stegenga
May 4, 2010·International Journal of Nursing Studies·Colleen M DavisonRonel Pretorius
Aug 16, 2014·Journal of Clinical Epidemiology·Suzanne E MahadyJonathan C Craig
Feb 7, 2013·Journal of Clinical Epidemiology·Anna-Bettina HaidichJohn P A Ioannidis
Apr 2, 2011·Journal of Clinical Epidemiology·Tiago V Pereira, John P A Ioannidis
Apr 16, 2016·Journal of Clinical Epidemiology·Andrea C TriccoDavid Moher
Oct 16, 2016·Evidence-based Medicine·Kamal R Mahtani
Jul 22, 2017·Anesthesia and Analgesia·Svjetlana DosenovicLivia Puljak
Nov 6, 2018·Pain Management·Naveen PoonaiLisa Hartling
Jan 27, 2018·Spinal Cord·Ross A Atkinson, Nicky A Cullum
Aug 25, 2019·The Journal of Orthopaedic and Sports Physical Therapy·Dafne Port NascimentoLeonardo Oliveira Pena Costa
Sep 8, 2020·BMC Medical Research Methodology·Lawrence MbuagbawLehana Thabane
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Feb 11, 2021·Evaluation and Program Planning·Michael J MarandaBrandn Green
Mar 26, 2021·Journal of Advanced Nursing·Helen Rose Noble, Joanna Smith

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