Non-Coding RNA: Role in Gestational Diabetes Pathophysiology and Complications.

International Journal of Molecular Sciences
Tiziana FilardiElisabetta Ferretti

Abstract

Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance that develops in the second or third trimester of pregnancy. GDM can lead to short-term and long-term complications both in the mother and in the offspring. Diagnosing and treating this condition is therefore of great importance to avoid poor pregnancy outcomes. There is increasing interest in finding new markers with potential diagnostic, prognostic and therapeutic utility in GDM. Non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs and circular RNAs, are critically involved in metabolic processes and their dysregulated expression has been reported in several pathological contexts. The aberrant expression of several circulating or placenta-related ncRNAs has been linked to insulin resistance and β-cell dysfunction, the key pathophysiological features of GDM. Furthermore, significant associations between altered ncRNA profiles and GDM-related complications, such as macrosomia or trophoblast dysfunction, have been observed. Remarkably, the deregulation of ncRNAs, which might be linked to a detrimental intrauterine environment, can lead to changes in the expression of target genes in the offspring, possibly contributing to the development of long...Continue Reading

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Citations

Oct 29, 2020·Journal of Endocrinological Investigation·G CatanzaroE Ferretti
Dec 19, 2020·International Journal of Environmental Research and Public Health·Amira Mohammed Ali, Hiroshi Kunugi
Dec 3, 2020·Biomedicines·Tiziana FilardiGiuseppina Catanzaro
May 1, 2021·Cells·Aleksandra LipkaMarta Majewska
Nov 27, 2021·Wiley Interdisciplinary Reviews. RNA·Neha JainBibekanand Mallick
Dec 23, 2021·Cell Death & Disease·Bowen LiuTianjiao Wang

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Methods Mentioned

BETA
biopsies
PCR

Software Mentioned

miRbase

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