Non-coding RNAs and exercise: pathophysiological role and clinical application in the cardiovascular system

Clinical Science
Clarissa P C GomesCardiolinc™ network

Abstract

There is overwhelming evidence that regular exercise training is protective against cardiovascular disease (CVD), the main cause of death worldwide. Despite the benefits of exercise, the intricacies of their underlying molecular mechanisms remain largely unknown. Non-coding RNAs (ncRNAs) have been recognized as a major regulatory network governing gene expression in several physiological processes and appeared as pivotal modulators in a myriad of cardiovascular processes under physiological and pathological conditions. However, little is known about ncRNA expression and role in response to exercise. Revealing the molecular components and mechanisms of the link between exercise and health outcomes will catalyse discoveries of new biomarkers and therapeutic targets. Here we review the current understanding of the ncRNA role in exercise-induced adaptations focused on the cardiovascular system and address their potential role in clinical applications for CVD. Finally, considerations and perspectives for future studies will be proposed.

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Citations

Aug 4, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Irving H Zucker, Timothy I Musch
Dec 21, 2018·Journal of Applied Physiology·Glenn D WadleyBianca C Bernardo
Jan 28, 2020·Circulation·Clarissa Pedrosa Costa GomesUNKNOWN EU-CardioRNA COST Action (CA17129)
Apr 9, 2020·Frontiers in Cell and Developmental Biology·Yuelin ZhangHonghua Ye
Aug 20, 2020·Circulation. Genomic and Precision Medicine·Saumya DasUNKNOWN American Heart Association Council on Genomic and Precision Medicine; Council on Arteriosclerosis, Thrombosis and Vascular B
Jun 10, 2021·Nature Reviews. Drug Discovery·Carolina Gubert, Anthony J Hannan
Nov 19, 2021·Journal of Applied Physiology·Bruno R A PelozinTiago Fernandes

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