Non-coding RNAs and nuclear architecture during epithelial-mesenchymal transition in lung cancer and idiopathic pulmonary fibrosis.

Cellular Signalling
Karla RubioGuillermo Barreto

Abstract

Lung cancer (LC) is the leading cause of cancer-related deaths worldwide. On the other hand, idiopathic pulmonary fibrosis (IPF) is the most common interstitial lung disease showing a prevalence of 20 new cases per 100,000 persons per year. Despite differences in cellular origin and pathological phenotypes, LC and IPF are lung diseases that share common features, including hyperproliferation of specific cell types in the lung, involvement of epithelial-mesenchymal transition (EMT) and enhanced activity of signaling pathways, such as tissue growth factor (TGFB), epidermal growth factor (EGF), fibroblast growth factor (FGF), wingless secreted glycoprotein (WNT) signaling, among others. EMT is a process during which epithelial cells lose their cell polarity and cell-cell adhesion, and acquire migratory and invasive properties to become mesenchymal cells. EMT involves numerous morphological hallmarks of hyperproliferative diseases, like cell plasticity, resistance to apoptosis, dedifferentiation and proliferation, thereby playing a central role during organ fibrosis and cancer progression. EMT was considered as an "all-or-none" process. In contrast to these outdated dichotomist interpretations, recent reports suggest that EMT occur...Continue Reading

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Citations

Jul 19, 2020·Journal of Biomedical Materials Research. Part a·Bowen TanJinfeng Liao
Aug 28, 2020·Frontiers in Molecular Biosciences·Keita UgaiYoshitoshi Kasuya
Jul 3, 2021·International Journal of Molecular Sciences·Yoshitoshi KasuyaShuichi Matsuda
Jul 19, 2021·Experimental Gerontology·Gurparsad Singh SuriManish Tiwari
Aug 8, 2021·International Journal of Molecular Sciences·Yair Romero, Arnoldo Aquino-Gálvez

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