Jul 14, 2019

Non-Coding RNAs and their Integrated Networks

Journal of Integrative Bioinformatics
Peijing ZhangMing Chen

Abstract

Eukaryotic genomes are pervasively transcribed. Besides protein-coding RNAs, there are different types of non-coding RNAs that modulate complex molecular and cellular processes. RNA sequencing technologies and bioinformatics methods greatly promoted the study of ncRNAs, which revealed ncRNAs' essential roles in diverse aspects of biological functions. As important key players in gene regulatory networks, ncRNAs work with other biomolecules, including coding and non-coding RNAs, DNAs and proteins. In this review, we discuss the distinct types of ncRNAs, including housekeeping ncRNAs and regulatory ncRNAs, their versatile functions and interactions, transcription, translation, and modification. Moreover, we summarize the integrated networks of ncRNA interactions, providing a comprehensive landscape of ncRNAs regulatory roles.

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References

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Citations

Mentioned in this Paper

Study
Cellular Process
Genome
RNA, Untranslated
Sequence Determinations, RNA
Transcription, Genetic
Bio-Informatics
Protein Biosynthesis
HSP40 Heat-Shock Proteins
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