Non-coding RNAs in cancer diagnosis and therapy

Non-coding RNA Research
Mahmood RasoolMohammad Sarwar Jamal

Abstract

Cancer invasion involves a series of fundamental heterogeneous steps, with each step being distinct in its type regarding its dependence on various oncogenic pathways. Over the past few years, researchers have been focusing on targeted therapies to treat malignancies relying not only on a single oncogenic pathway, but on multiple pathways. Scientists have recently identified potential targets in the human genome considered earlier as non-functional but the discovery of their potential role in gene regulation has put new insights to cancer diagnosis, prognosis and therapeutics. Non coding RNAs (ncRNAs) have been identified as the key gene expression regulators. Long non-coding RNA (lncRNAs) reveal diverse gene expression profiles in benign and metastatic tumours. Improved clinical research may lead to better knowledge of their biogenesis and mechanism and eventually be used as diagnostic biomarkers and therapeutic agents. Small non coding RNAs or micro RNA (miRNA) are capable of reprogramming multiple oncogenic cascades and, thus, can be used as target agents. This review is aimed to give a perspective of non coding transcription in cancer metastasis with an eye on rising clinical relevance of non coding RNAs and their mechanism...Continue Reading

Citations

Sep 16, 2018·Cellular Oncology (Dordrecht)·Rosario Castro-OropezaKarla Vazquez-Santillan
Jan 27, 2019·Non-coding RNA·Romana ButovaRoman Hajek
Apr 7, 2017·International Journal of Molecular Sciences·Mohammad Aslam Aslam KhanAjay Pratap Singh
Jun 22, 2017·Disease Markers·Luka BolhaDamjan Glavač
Dec 29, 2020·Seminars in Cancer Biology·Md Sahab UddinGhulam Md Ashraf
Dec 29, 2020·Cancer Letters·Arun NandwaniMalabika Datta
Apr 4, 2021·Genes·Parvaneh MahinfarBehzad Mansoori
Apr 4, 2021·International Journal of Molecular Sciences·Princess D RodriguezSeth Frietze
May 18, 2021·Non-coding RNA Research·Sadegh FattahiHaleh Akhavan-Niaki
Jun 30, 2021·Computers in Biology and Medicine·Dheeran RajarajanSyed Musthapa Meeran
Oct 26, 2021·Journal of Biomolecular Structure & Dynamics·Hung-Wei YangTa-Feng Tseng
Jan 14, 2022·Genes & Genomics·Agnik Haldar, Ajay Kumar Singh

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Methods Mentioned

BETA
transgenic
genetic modification
biopsies
flow cytometry
GTPase
xenografts
antisense oligonucleotides

Software Mentioned

BLAST
Ensemble

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