Non-coding RNAs in cardiovascular cell biology and atherosclerosis.

Cardiovascular Research
Francesca FasoloJason L Johnson

Abstract

Atherosclerosis underlies the predominant number of cardiovascular diseases and remains a leading cause of morbidity and mortality worldwide. The development, progression and formation of clinically relevant atherosclerotic plaques involves the interaction of distinct and over-lapping mechanisms which dictate the roles and actions of multiple resident and recruited cell types including endothelial cells, vascular smooth muscle cells, and monocyte/macrophages. The discovery of non-coding RNAs (ncRNAs) including microRNAs, long non-coding RNAs, and circular RNAs, and their identification as key mechanistic regulators of mRNA and protein expression has piqued interest in their potential contribution to atherosclerosis. Accruing evidence has revealed ncRNAs regulate pivotal cellular and molecular processes during all stages of atherosclerosis including cell invasion, growth, and survival; cellular uptake and efflux of lipids, expression and release of pro- and anti-inflammatory intermediaries, and proteolytic balance. The expression profile of ncRNAs within atherosclerotic lesions and the circulation have been determined with the aim of identifying individual or clusters of ncRNAs which may be viable therapeutic targets alongside d...Continue Reading

References

May 28, 1987·The New England Journal of Medicine·S GlagovG J Kolettis
Dec 31, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·J N WilcoxP A Marsden
Sep 23, 2003·Current Opinion in Lipidology·Norbert Leitinger
Jul 6, 2004·The Journal of Biological Chemistry·G Brett RobbPhilip A Marsden
Oct 23, 2004·Science·UNKNOWN ENCODE Project Consortium
Apr 22, 2005·The Journal of Biological Chemistry·Hsu Chao, Andrew P Spicer
Jul 29, 2005·The New England Journal of Medicine·Jaime García de Tena
Sep 6, 2005·Science·P CarninciUNKNOWN RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Feb 7, 2006·Cell Metabolism·Christine EsauBrett P Monia
Apr 1, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Takeshi SasakiAkihisa Iguchi
Sep 2, 2006·Cardiovascular Research·Johannes V van ThienenAnton J G Horrevoets
Apr 4, 2007·The Journal of Biological Chemistry·Jason E FishPhilip A Marsden
Apr 20, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Frank D KolodgieRenu Virmani
Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tamia A HarrisCharles J Lowenstein
Mar 15, 2008·Stroke; a Journal of Cerebral Circulation·Mar MatarinUNKNOWN ISGS investigators
Aug 13, 2008·Developmental Cell·Jason E FishDeepak Srivastava
Feb 14, 2009·Circulation Research·Wim Martinet, Guido R Y De Meyer
Jun 3, 2009·Genes & Development·David GatfieldUeli Schibler
Jul 14, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Olga JarinovaRuth McPherson
Aug 1, 2009·Current Opinion in Lipidology·Lillemor Mattsson Hultén, Max Levin
Dec 5, 2009·Nature Reviews. Immunology·Ira Tabas
Jan 9, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Lesca M HoldtDaniel Teupser
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Xiaomei QinNanping Wang
Mar 17, 2010·Biochemical and Biophysical Research Communications·Menno HoekstraErik A L Biessen
Jun 10, 2010·Clinical Science·Chiara TaurinoAnna F Dominiczak
Jul 3, 2010·Circulation Research·Stephan FichtlschererStefanie Dimmeler
Jul 14, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yun FangPeter F Davies
Oct 5, 2010·Basic Research in Cardiology·Benjamin MederWolfgang Rottbauer
Oct 29, 2010·Genome Biology·Simon Anders, Wolfgang Huber
Dec 24, 2010·Current Opinion in Lipidology·Carlos Fernández-HernandoKathryn J Moore
Feb 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Weihong XuUNKNOWN Inflammation and Host Response to Injury Large-Scale Collaborative Research Program
May 13, 2011·Pharmaceutical Research·Katsuhiko KidaTsuyoshi Yokoi
Jun 8, 2011·The Journal of Clinical Investigation·Katey J RaynerKathryn J Moore
Jul 26, 2011·Cardiology Research and Practice·Martina WeberCharles D Searles
Aug 6, 2011·Stroke; a Journal of Cerebral Circulation·Francesco CipolloneFiamma Buttitta

❮ Previous
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Citations

May 6, 2020·The FEBS Journal·Eithne Margaret Maguire, Qingzhong Xiao
Dec 29, 2020·Frontiers in Pharmacology·Jia LiuJunnan Wang
Feb 6, 2021·Cancer Management and Research·Jun-Yan WangSu-Ju Wei
Jun 25, 2021·Frontiers in Immunology·Xiaojun FengJianping Weng
Jul 9, 2021·Frontiers in Endocrinology·Vinay Singh TanwarRama Natarajan
Jul 13, 2021·Frontiers in Cardiovascular Medicine·Tiqun YangZhan-Peng Huang
Jul 17, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Amit Kumar RaiVenkata Naga Srikanth Garikipati
Aug 17, 2021·Thrombosis and Haemostasis·Johann Wojta

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