Non-coding RNAs in skeletal muscle regeneration

Non-coding RNA Research
Tristan J M Gonçalves, Anne-Sophie Armand

Abstract

Following injury, skeletal muscles can regenerate from muscle specific stem cells, called satellite cells. Quiescent in uninjured muscles, satellite cells become activated, proliferate and differentiate into myotubes. Muscle regeneration occurs following distinct main overlapping phases, including inflammation, regeneration and maturation of the regenerated myofibers. Each step of muscle regeneration is orchestrated through complex signaling networks and gene regulatory networks, leading to the expression of specific set of genes in each concerned cell type. Apart from the well-established transcriptional mechanisms involving the myogenic regulatory factors of the MyoD family, increasing data indicate that each step of muscle regeneration is controlled by a wide range of non-coding RNAs. In this review, we discuss the role of two classes of non-coding RNAs (microRNAs and long non-coding RNAs) in the inflammatory, regeneration and maturation steps of muscle regeneration.

Citations

Aug 14, 2019·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Kavitha Mukund, Shankar Subramaniam
Jul 1, 2020·Connective Tissue Research·Khairat Bahgat Youssef El Baradie, Mark W Hamrick
Apr 12, 2019·Scientific Reports·Tristan J M GonçalvesAnne-Sophie Armand
Jul 21, 2020·Epigenetics : Official Journal of the DNA Methylation Society·Nandini Karthik, Reshma Taneja
Jan 17, 2020·Cancers·Ruizhong Wang, Harikrishna Nakshatri
May 4, 2020·The Journal of Nutritional Biochemistry·Mailin GanLi Zhu
Nov 17, 2020·Frontiers in Genetics·Oscar Hernández-HernándezJ Manuel Hernández-Hernández
Mar 31, 2021·Communications Biology·Masashi FukuokaHirohiko Hohjoh
Aug 27, 2021·Journal of Cardiovascular Development and Disease·Amanda Pinheiro, Francisco J Naya

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Methods Mentioned

BETA
immunoprecipitation

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