Non-coding RNAs in skin cancers: An update

Non-coding RNA Research
Shivani B Kaushik, Nitin Kaushik

Abstract

Skin cancers are the most common form of cancer in humans. They can largely be categorized into Melanoma and Non-melanoma skin cancers. The latter mainly includes Squamous Cell Carcinoma (SCC) and Basal Cell Carcinoma (BCC), and have a higher incidence than melanomas. There has been a recent emergence of interest in the role of non-coding RNA's in pathogenesis of skin cancers. The transcripts which lack any protein coding capacity are called non-coding RNA. These non-coding RNA are further classified based on their length; small non-coding RNA (<200 nucleotides) and long non-coding RNA (>200 nucleotides). ncRNA They are involved at multiple transcriptional, post transcriptional and epigenetic levels, modulating cell proliferation, angiogenesis, senescence and apoptosis. Their expression pattern has also been linked to metastases, drug resistance and long term prognosis. They have both diagnostic and prognostic significance for skin cancers, and can also be a target for future therapies for cutaneous malignancies. More research is needed to further utilize their potential as therapeutic targets.

Citations

Jun 17, 2020·Cancer Biomarkers : Section a of Disease Markers·Kerong WuJianquan Hou
Dec 12, 2017·Journal of Cellular Physiology·Casey L RossRina Anvekar
Jun 16, 2018·The FEBS Journal·Gopinath M SundaramPrabha Sampath
Dec 20, 2018·Epigenomics·Katerina GrafanakiConstantinos Stathopoulos
Dec 10, 2020·International Journal of Molecular Sciences·Abdul Q KhanShahab Uddin
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Defeng QiFenghua Yu
Nov 27, 2020·Seminars in Cancer Biology·Mahendra Pratap KashyapMohammad Athar

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