Non-coding RNAs: Regulators of glioma cell epithelial-mesenchymal transformation

Pathology, Research and Practice
Sheng XinXin-Gen Zhu

Abstract

GBM (glioblastoma multiforme) is the most malignant form of glioma and is the most commonly occurring primary malignant brain tumour. GBM is difficult to completely excise, resulting in an extremely high recurrence rate. The occurrence of an aggressive glioma phenotype depends on EMT (epithelial-mesenchymal transformation), in which epithelial cells transform into mesenchymal cells by losing their cell-cell adhesion and polarity. NcRNAs (non-coding RNAs) play a significant role in the cellular progression from a normal phenotype to a cancerous phenotype. Recently, many studies have shown that there are two essential regulatory ncRNAs, miRNAs (microRNAs) and lncRNAs, which are closely related to EMT. In this review, we conducted a comprehensive investigation of the dysregulated lncRNAs and miRNAs in gliomas with particular attention to the function and regulatory mechanisms of several important lncRNAs and miRNAs, and we discussed their roles as glioma diagnostic and prognostic biomarkers and their potential clinical applications as therapeutic targets.

References

Aug 18, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xiao-Song WangWei-Feng Chen
Jan 17, 2009·Cancer Research·Christopher D ScharerCarlos S Moreno
Feb 19, 2009·British Journal of Cancer·J LopezT Crook
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Sep 5, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Iris GehrkeKarl-Anton Kreuzer
Aug 12, 2010·Cancer Prevention Research·Ilsiya IbragimovaPaul Cairns
Apr 6, 2011·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Hitomi TsuijiShinichi Nakagawa
Apr 15, 2011·Molecular Cancer·Ewan A GibbWan L Lam
Apr 26, 2011·TheScientificWorldJournal·Irena DimovVladisav Stefanovic
May 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jaroslaw JendrzejewskiAlbert de la Chapelle
Feb 5, 2013·Advances in Experimental Medicine and Biology·Thalia A FaraziThomas Tuschl
Jul 31, 2013·Advances in Cancer Research·Devanand Sarkar, Paul B Fisher
Aug 27, 2013·Cancer Letters·Ingrid Espinoza, Lucio Miele
Oct 11, 2013·Nature·Annalisa Di RuscioDaniel G Tenen
Dec 7, 2013·Cellular Signalling·Michaela Krausova, Vladimir Korinek
Oct 2, 2014·Journal of Cancer Research and Clinical Oncology·Danupon NantajitJian Jian Li
Dec 23, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Tsung-Hua HsiehEing-Mei Tsai
Aug 15, 2015·The Journal of Clinical Endocrinology and Metabolism·Jaroslaw JendrzejewskiAlbert de la Chapelle
Dec 10, 2015·International Journal of Oncology·Jian LiJingping Liu
Dec 15, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xudong ShengLing Zhao
Dec 20, 2015·Biochemical and Biophysical Research Communications·Xin HeChunjiang Yu
Jan 29, 2016·Journal of Experimental & Clinical Cancer Research : CR·Yang LiuQiong Wu
Feb 16, 2016·International Journal of Cancer. Journal International Du Cancer·Sonam Dhamija, Sven Diederichs
Feb 18, 2016·Genomics, Proteomics & Bioinformatics·Yiwen Fang, Melissa J Fullwood
Mar 26, 2016·Molecular Neurobiology·Dongsheng ZhaoZhou Fei
Jun 11, 2016·Cancer Medicine·Amanda SheaDeepak Kumar
Jul 2, 2016·Cell·M Angela NietoJean Paul Thiery
Jul 29, 2016·Proceedings of the National Academy of Sciences of the United States of America·Fang ChengJohn E Eriksson

❮ Previous
Next ❯

Citations

Jun 23, 2020·Mediators of Inflammation·Fakai WangZengchao Zhang
Aug 10, 2020·Journal of Bioenergetics and Biomembranes·Ping CongXiao-Ming Yu
Nov 13, 2019·Epigenetics & Chromatin·Dandan ZongPing Chen
May 19, 2021·Journal of Translational Medicine·Lei WangZhengwen He
Jun 25, 2021·BMC Neurology·Christopher DardisSurasak Phuphanich

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neurochemistry International
Xiaoqin Zhang, Gilberto Ka-Kit Leung
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Yuan-Feng GaoZhao-Qian Liu
© 2021 Meta ULC. All rights reserved