Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence

Nature Communications
G CostaE A Levashina

Abstract

Malaria is a fatal human parasitic disease transmitted by a mosquito vector. Although the evolution of within-host malaria virulence has been the focus of many theoretical and empirical studies, the vector's contribution to this process is not well understood. Here, we explore how within-vector resource exploitation would impact the evolution of within-host Plasmodium virulence. By combining within-vector dynamics and malaria epidemiology, we develop a mathematical model, which predicts that non-competitive parasitic resource exploitation within-vector restricts within-host parasite virulence. To validate our model, we experimentally manipulate mosquito lipid trafficking and gauge within-vector parasite development and within-host infectivity and virulence. We find that mosquito-derived lipids determine within-host parasite virulence by shaping development (quantity) and metabolic activity (quality) of transmissible sporozoites. Our findings uncover the potential impact of within-vector environment and vector control strategies on the evolution of malaria virulence.

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Citations

Aug 14, 2020·The Journal of Experimental Medicine·Elaine ThaiElena A Levashina
Oct 30, 2019·Evolution, Medicine, and Public Health·Philip L G BirgetSarah E Reece
May 7, 2019·Briefings in Functional Genomics·José L Ruiz, Elena Gómez-Díaz
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Dec 22, 2020·PLoS Pathogens·Perrine MarcenacFlaminia Catteruccia
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Aug 31, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Margarida Ressurreição, Christiaan van Ooij

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Methods Mentioned

BETA
transmission electron microscopy
flow cytometry
fluorescence microscopy
transgenic
PCR
dissections
FACS
FCS

Software Mentioned

FlowJo
R
GraphPad Prism
IDEAS
Axio
Vision ZEN
R Studio

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