PMID: 20650039Jul 24, 2010Paper

Non-concurrent dosing attenuates the pharmacokinetic interaction between amlodipine and simvastatin

International Journal of Clinical Pharmacology and Therapeutics
C G ParkH E Lim

Abstract

To explore if non-concurrent amlodipine dosing results in less drug interaction, the pharmacokinetic profiles, safety and efficacy endpoints were assessed following repeated doses of simvastatin, co-administered concurrently or non-concurrently with amlodipine in patients with coexisting hypertension and hyperlipidemia. Seventeen patients randomly received daily doses of 20 mg simvastatin and 5 mg amlodipine for 6 weeks, either with both drugs at 7:00 PM (concurrent) or with simvastatin at 7:00 PM followed by amlodipine at 11:00 PM (non-concurrent). The maximum plasma concentration (Cmax) and the area under the concentration-time curve up to the last quantifiable concentration (AUClast) were estimated at steady state. Lipid profiles and blood pressure values were also compared between the concurrent and non-concurrent groups. The Cmax and AUClast and of simvastatin acid in the non-concurrent amlodipine dosing group were 63.2% and 66.0%, respectively, of the values obtained in the concurrent group (1.2 +/- 1.0 vs. 1.9 +/- 0.9 ng/ml and 10.3 +/- 8.3 vs. 15.6 +/- 7.5 h ng/ml, respectively, mean +/- standard deviation). Changes from baseline in lipid profile and blood pressure were comparable between the groups. Non-concurrent dosi...Continue Reading

Citations

Dec 18, 2013·BMC Public Health·Hasniza Zaman Huri, Lee Chai Ling
Mar 16, 2012·Expert Opinion on Drug Safety·Matilda Florentin, Moses S Elisaf
Aug 8, 2012·Expert Opinion on Drug Safety·Stefano Bellosta, Alberto Corsini
Jun 20, 2012·Biochimica Et Biophysica Acta·Olivier PeyruchaudMarion David
Aug 24, 2013·Drug Metabolism and Pharmacokinetics·Hankil SonKyungsoo Park
Nov 20, 2010·Journal of the American College of Cardiology·Giampaolo NiccoliFilippo Crea
Dec 22, 2012·JACC. Cardiovascular Interventions·Steven P DunnDavid J Moliterno
Nov 22, 2013·The Annals of Pharmacotherapy·Bethany R ShouldersMichelle Z Farland
Oct 24, 2017·Expert Opinion on Drug Safety·Stefano Bellosta, Alberto Corsini
Jun 5, 2013·The American Journal of Gastroenterology·Belén MorónGovind K Makharia
Jan 31, 2019·Ciência & saúde coletiva·Ronara Camila de Souza Groia VelosoAdriano Max Moreira Reis
Oct 29, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Rhianna M TuchschererJoseph J Saseen

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