Non-contrast-enhanced MRI of the pulmonary blood volume using two-compartment-modeled T1 -relaxation

Journal of Magnetic Resonance Imaging : JMRI
Thomas GaassFrederik Laun

Abstract

To introduce a novel technique, based on a two-compartment model and nonselective inversion recovery (TCIR) for the non-contrast-enhanced evaluation of the fractional pulmonary blood volume (fPBV). Ten healthy volunteers and one patient with focal lung destruction underwent examination with conventional magnetic resonance imaging (MRI) and TCIR. The reproducibility of TCIR was evaluated statistically, analyzing three consecutive measurement series. In order to evaluate the sensitivity of TCIR, the influence of gravitation on fPBV values along the anterior-posterior direction was assessed. Therefore, two transverse parameter maps of each volunteer in supine and prone position were acquired and analyzed. A comparison of patient images from TCIR-MRI, dynamic contrast-enhanced (DCE) MRI, and contrast-enhanced computed tomography (CT) was performed visually. The statistical evaluation showed significant similarity within the volunteer group, proving reproducibility. The detected slope of the fPBV values in anterior-posterior direction for both supine and prone position demonstrated the sensitivity of TCIR to the gravitational effect on the pulmonary blood distribution. The comparison between CT, DCE-, and TCIR-MRI patient datasets s...Continue Reading

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Citations

Aug 21, 2015·Expert Review of Clinical Immunology·Ruth HartleySumit Gupta
Oct 21, 2015·European Journal of Radiology·Thomas GaassJulien Dinkel
Jan 22, 2015·Journal of Magnetic Resonance Imaging : JMRI·Simon M F TriphanPeter M Jakob
Jun 20, 2014·Journal of Magnetic Resonance Imaging : JMRI·Flavio CarinciPeter M Jakob
Mar 14, 2020·Journal of Magnetic Resonance Imaging : JMRI·Andreas Voskrebenzev, Jens Vogel-Claussen
Jul 3, 2020·Journal of Magnetic Resonance Imaging : JMRI·Simon M F TriphanMark O Wielpütz
Apr 11, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Julian GlandorfJens Vogel-Claussen

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