Non-contrast MR imaging of blood-brain barrier permeability to water

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Zixuan LinHanzhang Lu

Abstract

Many brain diseases are associated with an alteration in blood-brain barrier (BBB) and its permeability. Current methods using contrast agent are primarily sensitive to major leakage of BBB to macromolecules, but may not detect subtle changes in BBB permeability. The present study aims to develop a novel non-contrast MRI technique for the assessment of BBB permeability to water. The central principle is that by measuring arterially labeled blood spins that are drained into cerebral veins, water extraction fraction (E) and permeability-surface-area product (PS) of BBB can be determined. Four studies were performed. We first demonstrated the proof-of-principle using conventional ASL with very long post-labeling delays (PLD). Next, a new sequence, dubbed water-extraction-with-phase-contrast-arterial-spin-tagging (WEPCAST), and its Look-Locker (LL) version were developed. Finally, we demonstrated that the sensitivity of the technique can be significantly enhanced by acquiring the data under mild hypercapnia. By combining a strong background suppression with long PLDs (2500-4500 ms), ASL spins were reliably detected in the superior sagittal sinus (SSS), demonstrating the feasibility of measuring this signal. The WEPCAST sequence eli...Continue Reading

References

Feb 1, 1976·The American Journal of Physiology·M E RaichleM M Ter-Pogossian
Jan 1, 1977·Microvascular Research·O B PaulsonN A Lassen
Sep 1, 1991·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M S BerridgeF Miraldi
Feb 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P S Tofts, A G Kermode
Oct 1, 1987·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·P HerscovitchM J Welch
Sep 1, 1974·Circulation Research·J O EichlingM M Ter-Pogossian
May 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C SchwarzbauerA Haase
May 9, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J B Gonzalez-AtJ A Detre
Jun 6, 2000·Advanced Drug Delivery Reviews·E M Cornford, S Hyman
Sep 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K S St LawrenceA C McLaughlin
Apr 27, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J ZhouP C van Zijl
Sep 11, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J R EwingJ Fenstermacher
Oct 25, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M GüntherL R Schad
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Laura M Parkes, Paul S Tofts
Jul 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Emmanuel L BarbierMichel Décorps
Jul 24, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jeroen HendrikseXavier Golay
Dec 1, 1959·The American Journal of Physiology·E M RENKIN
Jan 29, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K S St Lawrence, J Wang
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ka-loh LiNorbert Schuff
Jun 14, 2005·Medical Image Analysis·Matthias J P van OschJeroen van der Grond
Jul 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dairon M GarciaDavid C Alsop
Sep 30, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·María A Fernández-SearaJohn A Detre
Jan 18, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Esben Thade PetersenXavier Golay
Apr 6, 2006·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Tae Kim, Seong-Gi Kim
Sep 14, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jiongjiong WangKeith S St Lawrence
Jul 27, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·John P CarrGeoff J M Parker
Sep 16, 2008·Neurobiology of Disease·Karin E Sandoval, Ken A Witt
Feb 13, 2009·Psychiatry Research·John M StarrJoanna Wardlaw
Mar 26, 2009·Acta Neuropathologica·Robert D Bell, Berislav V Zlokovic
Mar 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Philip M RobsonDavid C Alsop
Apr 24, 2009·NMR in Biomedicine·Uma S YezhuvathHanzhang Lu
Aug 8, 2009·NeuroImage·Esben Thade PetersenUNKNOWN all named co-authors of the QUASAR test-retest study
Aug 12, 2009·Neurobiology of Disease·N Joan AbbottDavid J Begley
Feb 27, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sina AslanHanzhang Lu
Jun 11, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Thomas W OkellPeter Jezzard
Jun 26, 2010·Journal of Magnetic Resonance Imaging : JMRI·Jinsoo UhHanzhang Lu
Aug 27, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peiying LiuHanzhang Lu
Aug 23, 2011·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Keith S St LawrenceDanny J J Wang
Sep 20, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Patrick W Hales, Chris A Clark
Sep 29, 2012·Journal of Magnetic Resonance Imaging : JMRI·Johannes GregoriMatthias Günther

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Citations

Dec 19, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xingfeng ShaoDanny J J Wang
May 9, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Dengrong JiangPeiying Liu
Apr 30, 2019·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael J ThrippletonJoanna M Wardlaw
May 18, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Francesca BagnatoUNKNOWN NAIMS Cooperative
Sep 17, 2020·Translational Stroke Research·Michael S StringerJoanna M Wardlaw
May 14, 2020·International Journal of Molecular Sciences·Alison Cash, Michelle H Theus
May 1, 2020·Nature Communications·P G EvansJ A Wells
Feb 10, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zixuan LinHanzhang Lu
Dec 29, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yuning GuXin Yu
Mar 8, 2021·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Paula TrujilloDaniel O Claassen
May 6, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Brian T GoldDanny J J Wang
May 28, 2021·Annals of Neurology·Zixuan LinHanzhang Lu
Nov 30, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yonni FriedlanderAndrea Kassner
Dec 16, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Daniel D CumminsMatthew R Amans
Dec 21, 2021·Frontiers in Neuroscience·Amnah MahrooMatthias Günther

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