PMID: 15330053Aug 28, 2004Paper

Non-conventional injection molding of poly(lactide) and poly(epsilon-caprolactone) intended for orthopedic applications

Journal of Materials Science. Materials in Medicine
H AltpeterJ Feijen

Abstract

Biodegradable polymers such as poly(lactide) (PLA) and poly(epsilon-caprolactone) (PCL) are increasingly used in biomedical applications as temporary implants. However, melt processing of these materials in particular of PLA is difficult due to the temperature sensitivity. Within this study, PLA and PCL were injection molded conventionally and by using the process shear controled orientation in injection molding (SCORIM) in order to investigate the effect of processing parameters on the physical properties of the moldings. Therefore, flexural testing, differential scanning calorimetry (DSC), wide-angle X-ray diffraction (WAXD), molecular weight (MW) and orientation measurements were performed. PLA showed high sensitivity to melt temperature. In the case of amorphous poly(DL-lactide), the molecular weight and subsequently the ductility is substantially reduced by processing at higher melt temperatures. In the case of crystallizable poly(L-lactide), higher melt temperatures and shear induced by the SCORIM process resulted in enhanced crystallinity, which compromised the mechanical properties. Generally, SCORIM processing improved the mechanical properties, in particular the ductility, by orientating the molecular structure. PCL w...Continue Reading

Citations

Apr 1, 2011·Drug Development and Industrial Pharmacy·Jingwen HouTingting Tang
Jun 7, 2013·Drug Delivery·Adriana De Fátima PereiraGisele Rodrigues Da Silva
Jul 2, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Angel M CarcabosoAlejandro Sosnik
Feb 26, 2013·Pharmaceutical Development and Technology·Weiluan ChenLiang Cheng
Dec 30, 2017·Journal of Materials Science. Materials in Medicine·H LittleF Buchanan

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