PMID: 9540840Apr 16, 1998Paper

Non-conventional modification of low density lipoproteins: chemical models for macrophage recognition of oxidized LDL

Biochimica Et Biophysica Acta
George HoppeHenry F Hoff

Abstract

To define the structural and chemical criteria governing recognition of oxidized LDL (oxLDL) by mouse peritoneal macrophages (MPM), we exposed LDL to novel chemical modification agents that induce defined neutralizing and non-neutralizing alterations of lysine as models for distinct apoB adducts present in oxLDL. We found some exceptions to the usual notion that neutralization of lysine positive charges is the principal determinant governing MPM recognition. In addition, competitive binding experiments using chemically modified 125I-LDL preparations revealed that, whereas some modifications engendered recognition principally by the classical scavenger receptor class A (SRA), as seen for acetylated LDL (acLDL), chemical models of advanced aldehydic modifications of LDL led instead to MPM uptake mainly by oxLDL receptors distinct from SRA.

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Citations

Jan 25, 2003·Free Radical Biology & Medicine·Eugene A PodrezHenry F Hoff
Apr 9, 2010·Clinical and Experimental Pharmacology & Physiology·Eugene A Podrez
Nov 28, 2012·Journal of Hepatology·Sofie M A WalenberghRonit Shiri-Sverdlov
Jul 23, 2005·Annals of the New York Academy of Sciences·Naila AhmedPaul J Thornalley

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