Non-covalent synthesis of supermicelles with complex architectures using spatially confined hydrogen-bonding interactions

Nature Communications
Xiaoyu LiIan Manners

Abstract

Nature uses orthogonal interactions over different length scales to construct structures with hierarchical levels of order and provides an important source of inspiration for the creation of synthetic functional materials. Here, we report the programmed assembly of monodisperse cylindrical block comicelle building blocks with crystalline cores to create supermicelles using spatially confined hydrogen-bonding interactions. We also demonstrate that it is possible to further program the self-assembly of these synthetic building blocks into structures of increased complexity by combining hydrogen-bonding interactions with segment solvophobicity. The overall approach offers an efficient, non-covalent synthesis method for the solution-phase fabrication of a range of complex and potentially functional supermicelle architectures in which the crystallization, hydrogen-bonding and solvophobic interactions are combined in an orthogonal manner.

References

Nov 23, 2000·Nature·L J PrinsD N Reinhoudt
Nov 27, 2001·Science·J D HartgerinkS I Stupp
Mar 30, 2002·Science·George M Whitesides, Bartosz Grzybowski
Mar 13, 2003·Journal of the American Chemical Society·Rainer ErhardtAxel H E Müller
Oct 2, 2004·Science·Darrin J PochanKaren L Wooley
Oct 2, 2004·Science·Zhibo LiTimothy P Lodge
Oct 24, 2006·Chemical Society Reviews·Rachel K O'ReillyKaren L Wooley
Aug 2, 2007·Nature Materials·Sharon C Glotzer, Michael J Solomon
Aug 4, 2007·Science·Honggang CuiDarrin J Pochan
Sep 27, 2008·Science·Chuanbing TangCraig J Hawker
Mar 17, 2009·Journal of the American Chemical Society·Andreas WaltherAxel H E Müller
May 22, 2009·Nature·Shawn M DouglasWilliam M Shih
Jul 9, 2009·Angewandte Chemie·John DupontHiroshi Jinnai
Apr 24, 2010·Nature Chemistry·Mauri A KostiainenRoeland J M Nolte
Jun 24, 2010·Nature Chemistry·Joe B GilroyIan Manners
Dec 3, 2010·Nature Chemistry·Pik Kwan LoHanadi F Sleiman
Mar 20, 2012·Nature Communications·André H GröschelAxel H E Müller
Jul 28, 2012·Journal of the American Chemical Society·André H GröschelAxel H E Müller
Aug 4, 2012·Science·Paul A RuparIan Manners
Aug 8, 2012·Journal of the American Chemical Society·Joachim SchmelzHolger Schmalz
Nov 5, 2013·Nature·André H GröschelAxel H E Müller
Feb 22, 2014·Nature Chemistry·Soichiro OgiMasayuki Takeuchi
Mar 7, 2014·Nature Communications·Zachary M HudsonIan Manners
May 28, 2014·Nature Communications·Lin JiaMitchell A Winnik

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Citations

Feb 16, 2016·Journal of the American Chemical Society·Xiaoyu LiIan Manners
Aug 24, 2016·Journal of the American Chemical Society·Xiaoyu LiIan Manners
Jun 28, 2016·Chemical Society Reviews·Rebekah L N HailesIan Manners
Mar 22, 2018·Nature Communications·Gerald GuerinMitchell A Winnik
Aug 28, 2019·Nature Communications·Ming-Peng ZhuoLiang-Sheng Liao
Nov 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dae-Woo LeeDai-Soo Lee
Jun 20, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dae-Woo LeeDai-Soo Lee
Oct 7, 2016·Chemical Communications : Chem Comm·Kai ZhangEduardo Mendes
Apr 15, 2021·Journal of the American Chemical Society·Yifan ZhangIan Manners
May 27, 2021·Nature Communications·Oleksandr ShyshovMax von Delius
Apr 6, 2020·Chemical Science·Garion E J HicksDwight S Seferos
Jun 25, 2021·Chemical Science·Liam MacFarlaneIan Manners
Sep 6, 2018·Journal of the American Chemical Society·Christopher M TongeZachary M Hudson
Mar 20, 2019·Journal of the American Chemical Society·Beatrice AdelizziE W Meijer
Oct 3, 2018·Journal of the American Chemical Society·Théophile PelrasMarkus Müllner
Nov 18, 2017·Journal of the American Chemical Society·Lucas R ParentNathan C Gianneschi
Jul 16, 2019·Journal of the American Chemical Society·Wolfgang WagnerFrank Würthner
Aug 29, 2021·Pharmaceutics·William T FerreiraSimon M Cutting

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Methods Mentioned

BETA
transmission electron microscopy
confocal microscopy
electron microscopy
fluorescence spectroscopy

Software Mentioned

LSCM
ImageJ

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