Non-crossbridge stiffness in active muscle fibres

The Journal of Experimental Biology
B ColombiniM A Bagni

Abstract

Stretching of an activated skeletal muscle induces a transient tension increase followed by a period during which the tension remains elevated well above the isometric level at an almost constant value. This excess of tension in response to stretching has been called 'static tension' and attributed to an increase in fibre stiffness above the resting value, named 'static stiffness'. This observation was originally made, by our group, in frog intact muscle fibres and has been confirmed more recently, by us, in mammalian intact fibres. Following stimulation, fibre stiffness starts to increase during the latent period well before crossbridge force generation and it is present throughout the whole contraction in both single twitches and tetani. Static stiffness is dependent on sarcomere length in a different way from crossbridge force and is independent of stretching amplitude and velocity. Static stiffness follows a time course which is distinct from that of active force and very similar to the myoplasmic calcium concentration time course. We therefore hypothesize that static stiffness is due to a calcium-dependent stiffening of a non-crossbridge sarcomere structure, such as the titin filament. According to this hypothesis, titin, ...Continue Reading

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Citations

Jul 18, 2018·Physiotherapy Theory and Practice·Haris BegovicNecla Ozturk
Nov 26, 2019·The American Journal of Sports Medicine·Angelina M VeraJoshua D Harris
Apr 5, 2018·Frontiers in Neuroscience·Yury Ivanenko, Victor S Gurfinkel
Jul 19, 2018·Frontiers in Physiology·Britt SchoenrockDieter Blottner
Oct 24, 2017·Journal of Neuroengineering and Rehabilitation·Richard L LieberWalter Herzog

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