PMID: 9546671Apr 18, 1998Paper

Non-detergent sulphobetaines enhance the recovery of membrane and/or cytoskeleton-associated proteins and active proteases from erythrocytes infected by Plasmodium falciparum

European Journal of Biochemistry
T BlisnickC Braun Breton

Abstract

A better understanding of the causative agent's biology and the definition of new targets for the development of drugs and/or specific immune responses is necessary to face the spred of drug-resistant malaria in developing countries and the absence of an efficient vaccine against this most important infectious disease. Non-detergent sulphobetaines enhance the recovery and isoelectric focussing of active Plasmodium falciparum proteases, cytoskeleton-associated proteins and Maurer's cleft-associated proteins. This is a significant advantage for the purification of such proteins and might help pinpoint their role for red blood cell rupture and merozoite release.

Citations

Apr 7, 2005·Molecular and Biochemical Parasitology·Thierry BlisnickCatherine Braun Breton
Nov 23, 2000·Molecular and Biochemical Parasitology·T BlisnickC Braun Breton
Mar 8, 2008·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Yoshiaki SuwaYuriko Yamagata
Jan 8, 2010·Protein Science : a Publication of the Protein Society·Kazutoshi YasuiTakeshi Ishimizu
Apr 8, 2017·Proteomes·Matthew P PadulaSteven P Djordjevic
Jun 23, 2006·Proteomics·Cristina-Maria Vâlcu, Katja Schlink
Sep 21, 2000·The Journal of Biological Chemistry·F ValleeP L Howell

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