Non-Directed Cross-Dehydrogenative (Hetero)arylation of Allylic C(sp3 )-H bonds enabled by C-H Activation

Angewandte Chemie
Andreas LerchenFrank Glorius

Abstract

Herein, we report the selective, non-directed and cross-dehydrogenative coupling of allylic C(sp3 )-H bonds with C(sp2 )-H bonds of (hetero)arenes. The methodology employs olefins and (hetero)arenes which are abundantly available chemical feedstocks, and could be applied in late-stage functionalization reactions of pharmaceuticals. Furthermore, the system exclusively delivers the allylic C-C coupling products highlighting the preservation of the olefin substitution pattern for further derivatization.

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Citations

Dec 14, 2018·Chemical Communications : Chem Comm·Jun ZhengBernhard Breit
Aug 15, 2018·Angewandte Chemie·Gwilherm Evano, Cédric Theunissen
Jul 30, 2019·Angewandte Chemie·Pravas DoluiDebabrata Maiti
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Oct 6, 2020·Chemical Communications : Chem Comm·Amaan M KazerouniSimon B Blakey
Jan 6, 2021·Angewandte Chemie·Shobhan MondalFrank Glorius
Jan 8, 2021·Angewandte Chemie·Franco Della-FeliceAntonio M Echavarren
Mar 4, 2021·ACS Central Science·Toryn DaltonFrank Glorius
Jul 16, 2020·Journal of the American Chemical Society·Caitlin M B FarrSimon B Blakey
Jul 10, 2019·The Journal of Organic Chemistry·Hang LuoPingfan Li
Jul 7, 2020·Organic Letters·You-Ke ChenYi Lu
Aug 17, 2019·The Journal of Organic Chemistry·Amaan M KazerouniSimon B Blakey
Mar 3, 2020·Journal of the American Chemical Society·Robert J HarrisSimon B Blakey
Aug 23, 2019·The Journal of Organic Chemistry·Pinki Sihag, Masilamani Jeganmohan
Apr 3, 2020·Journal of the American Chemical Society·Weilong XieSukbok Chang

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