Non enzymatic glycosylation increases platelet aggregating potency of collagen from placenta of diabetic human beings

Biochemical and Biophysical Research Communications
A Le PapeJ P Muh

Abstract

Pepsin extracted collagen and an acid soluble glycoprotein were purified from placentas of normal and diabetic human beings. Diabetic samples exhibit a significant increase in ketoamine-linked glucose whereas both amino acid and carbohydrate composition were unaffected. This excess non enzymatic condensation of glucose on free amino-groups was found to increase platelet aggregating potency of these proteins independently of any modification in fiber morphology.

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Citations

Nov 1, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Yarat, N Emekli
Sep 6, 1984·The New England Journal of Medicine·J F Mustand, M A Packham
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May 19, 1988·The New England Journal of Medicine·M BrownleeH Vlassara
Sep 20, 1988·Journal of Molecular Biology·S TanakaE F Eikenberry

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