PMID: 7026742Oct 1, 1981Paper

Non-essential role of dietary factors in the development of diabetes in ob/ob mice

The Journal of Nutrition
P U Dubuc

Abstract

Hyperinsulinemia is detectable in C57BL/6J ob/ob mice as early as 6 days following birth. Although these mice continue to have very high circulating insulin levels during weaning, they exhibit a transition from mild hypoglycemia to hyperglycemia between 17 and 28 days of age. In the present studies, I examined the roles of the dietary changes associated with weaning (unlimited access to food and its altered composition), and of glucagon and corticosterone overproduction, to the phenotypic differences in glucose regulation observed at this time. The results indicated that neither continuation of the preweaning milk diet nor severely limiting the daily intake of a stock commercial diet significantly affected the initial appearance of glycoregulatory disturbances in ob/ob mice or the maintenance of their hyperinsulinemia. However, the diets reduced the severity of the diabetes. Large phenotype differences in glucagon and corticosterone production were generally associated with the periweaning glycemic changes in both dieted and ad libitum-fed obese mice. Since several previous studies indicate that the tissue responsiveness to insulin is "normal" in ob/ob mice at this time, the increased production of these diabetogenic hormones m...Continue Reading

Citations

Sep 1, 1992·The American Journal of Physiology·P U Dubuc
Sep 1, 1997·The Journal of Nutrition·G L Wolff
May 1, 1985·Journal of the Neurological Sciences·A SenaG Rebel
Nov 1, 1984·Clinics in Endocrinology and Metabolism·P Trayhurn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
P U DubucP L Willis
Experimental and Clinical Endocrinology
S YouG Dörner
© 2021 Meta ULC. All rights reserved