Non-falciparum malaria infections in pregnant women in West Africa

Malaria Journal
John E WilliamsDaniel Chandramohan

Abstract

Non-Plasmodium falciparum malaria infections are found in many parts of sub-Saharan Africa but little is known about their importance in pregnancy. Blood samples were collected at first antenatal clinic attendance from 2526 women enrolled in a trial of intermittent screening and treatment of malaria in pregnancy (ISTp) versus intermittent preventive treatment (IPTp) conducted in Burkina Faso, The Gambia, Ghana and Mali. DNA was extracted from blood spots and tested for P. falciparum, Plasmodium vivax, Plasmodium malariae and Plasmodium ovale using a nested PCR test. Risk factors for a non-falciparum malaria infection were investigated and the influence of these infections on the outcome of pregnancy was determined. P. falciparum infection was detected frequently (overall prevalence by PCR: 38.8 %, [95 % CI 37.0, 40.8]), with a prevalence ranging from 10.8 % in The Gambia to 56.1 % in Ghana. Non-falciparum malaria infections were found only rarely (overall prevalence 1.39 % [95 % CI 1.00, 1.92]), ranging from 0.17 % in the Gambia to 3.81 % in Mali. Ten non-falciparum mono-infections and 25 mixed falciparum and non-falciparum infections were found. P. malariae was the most frequent non-falciparum infection identified; P. vivax wa...Continue Reading

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Citations

Apr 25, 2017·Expert Review of Vaccines·Caroline PehrsonMorten A Nielsen
Feb 19, 2017·Cold Spring Harbor Perspectives in Medicine·Michal Fried, Patrick E Duffy
Oct 11, 2017·The American Journal of Tropical Medicine and Hygiene·Shereen KatrakBryan Greenhouse
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Jan 29, 2021·Critical Reviews in Microbiology·Eniyou C OrieroAlfred Amambua-Ngwa

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Methods Mentioned

BETA
biopsies
PCR

Clinical Trials Mentioned

NCT01084213

Software Mentioned

IPTp
SP

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