Non-familial olivopontocerebellar atrophy combined with late onset Alzheimer's disease: a clinico-pathological case report

Journal of the Neurological Sciences
K KobayashiY Koshino

Abstract

A 76-year-old woman with olivopontocerebellar atrophy (OPCA) presented with progressive intellectual deterioration. She showed cerebellar ataxia and muscle atrophy and weakness, and gradually developed generalized dementia with visuospatial disturbance. An autopsy revealed numerous senile plaques (SPs), neurofibrillary tangles (NFTs) and neuropil threads particularly in the CA1, subiculum and entorhinal cortex and to a lesser degree in the cerebral neocortex shown by immunostaining and specific silver impregnation techniques. The nucleus basalis of Meynert had numerous NFTs with fibrillary gliosis and neuronal cell loss. The basis pontis was markedly atrophied and the pontine nucleus had severe neuronal depopulation and gliosis. The pontine transverse fibers were demyelinated with their axons being fragmented. The cerebellar white matter was also severely degenerated. The striatum, Onuf's and intermediolateral nuclei of the spinal cord remained unchanged. Ubiquitin immunohistochemistry and Gallyas silver impregnation technique revealed oligodendroglial inclusions in the pontine nucleus, corticopontine tract, cerebral and cerebellar white matter. On double immunostaining of KP1 and ubiquitin, globular neurite SPs encircled by KP...Continue Reading

References

Sep 1, 1992·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·K KobayashiN Yamaguchi
Feb 1, 1992·Brain : a Journal of Neurology·T W RobbinsC D Marsden
Sep 1, 1990·Journal of Neuropathology and Experimental Neurology·Y NakazatoH Yamaguchi
Jan 1, 1991·Acta Neuropathologica·D S Horoupian, D W Dickson
May 1, 1970·Medicine·B W Konigsmark, L P Weiner
Jun 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·N J Rothwell, P J Strijbos
Jan 1, 1993·Acta Neuropathologica·K Renkawek, M W Horstink
Jan 1, 1993·Brain Pathology·J LoweM Landon
Jan 1, 1993·Glia·P L McGeerE G McGeer
Feb 20, 1998·Dementia and Geriatric Cognitive Disorders·K KobayashiF Koshino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Alzheimer's Disease: Microglia

Microglia are a type of glial cell found throughout the brain and spinal cord. Microglia have been found to be associated with Alzheimer's disease development and progression. Here are the latest discoveries pertaining to Alzheimer's disease and microglia.

Ataxias

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on different types of ataxias here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.