Non-fatal major bleeding during treatment with vitamin K antagonists: influence of soluble thrombomodulin and mutations in the propeptide of coagulation factor IX

Journal of Thrombosis and Haemostasis : JTH
J F van der HeijdenP H Reitsma

Abstract

The key complication of treatment with vitamin K antagonists (VKAs) is bleeding. The major determinant of VKA-induced bleeding is the intensity of anticoagulation. Individual patient characteristics may also influence bleeding risk. In addition, soluble thrombomodulin (s-TM) levels and mutations in the propeptide of factor (F)IX are important candidate risk factors in this respect. A matched case-control study was designed to search for risk factors that predict bleeding during VKA treatment. We selected cases that had experienced major bleeding during treatment with VKA and matched controls without bleeding complications from the databases of two Thrombosis Services. The controls were matched for indication of treatment, age, gender, type of anticoagulant used and whether or not treatment with VKA was stopped. DNA and plasma were stored of all cases and controls. In total 110 patients and 220 controls consented to participate. The results indicate that s-TM levels, measured by ELISA, may be a risk indicator for bleeding [crude odds ratio 3.25 for the highest quartile vs. the lowest quartile (95% confidence interval 1.40, 7.51)]. Three novel mutations, determined by direct sequencing, in the gene portion encoding the propeptide...Continue Reading

References

Jul 12, 1993·Archives of Internal Medicine·F J van der MeerE Briët
Oct 1, 1996·The Journal of Clinical Investigation·K ChuK A High
Aug 14, 1998·Diabetic Medicine : a Journal of the British Diabetic Association·A D Blann, G Y Lip
Nov 24, 1999·The American Journal of Medicine·R H WhiteP S Romano
Feb 7, 2001·Chest·M N LevineC Kearon
May 11, 2002·Critical Care Medicine·Konrad ReinhartMichael Meisner

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Citations

Oct 19, 2006·Human Genetics·Mia WadeliusPanos Deloukas
Sep 20, 2006·The Pharmacogenomics Journal·M Wadelius, M Pirmohamed
Nov 5, 2005·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Dolors TàssiesJoan Carles Reverter
Oct 6, 2005·PLoS Medicine·Pieter H ReitsmaHarry R Büller
Mar 8, 2013·Vascular Health and Risk Management·Nancy El-HelouPascale Salameh
Sep 16, 2009·Pharmacogenetics and Genomics·Andrea L JorgensenMunir Pirmohamed
May 19, 2006·Journal of Thrombosis and Haemostasis : JTH·A A GarciaP H Reitsma
Aug 21, 2013·Journal of Clinical Epidemiology·Nienke van ReinWillem M Lijfering
Jan 22, 2009·Science and Engineering Ethics·Daan SchuurbiersJulian Kinderlerer
May 14, 2020·Thrombosis Research·Håkon S JohnsenJohn-Bjarne Hansen

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