Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors

The European Journal of Neuroscience
Isaac ShemerTibor Harkany

Abstract

Cognitive decline in Alzheimer's disease (AD) stems from the progressive dysfunction of synaptic connections within cortical neuronal microcircuits. Recently, soluble amyloid beta protein oligomers (Abeta(ol)s) have been identified as critical triggers for early synaptic disorganization. However, it remains unknown whether a deficit of Hebbian-related synaptic plasticity occurs during the early phase of AD. Therefore, we studied whether age-dependent Abeta accumulation affects the induction of spike-timing-dependent synaptic potentiation at excitatory synapses on neocortical layer 2/3 (L2/3) pyramidal cells in the APPswe/PS1dE9 transgenic mouse model of AD. Synaptic potentiation at excitatory synapses onto L2/3 pyramidal cells was significantly reduced at the onset of Abeta pathology and was virtually absent in mice with advanced Abeta burden. A decreased alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/N-methyl-D-aspartate (NMDA) receptor-mediated current ratio implicated postsynaptic mechanisms underlying Abeta synaptotoxicity. The integral role of Abeta(ol)s in these processes was verified by showing that pretreatment of cortical slices with Abeta((25-35)ol)s disrupted spike-timing-dependent synaptic potentiation...Continue Reading

References

May 15, 1987·The Journal of Comparative Neurology·P L GabbottD Whitteridge
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·W LinkD Kuhl
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·U StäubliG Lynch
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·M R MehtaB L McNaughton
Aug 1, 1997·Experimental Neurology·M IngvarG Lynch
Feb 26, 1999·Journal of Neurophysiology·S N YangR S Zucker
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·V DerkachT R Soderling
Nov 24, 1999·Biochemical and Biophysical Research Communications·Z SzabóB Penke
Jan 7, 2000·Neuron·T J Sejnowski
Aug 3, 2001·Nature Reviews. Neuroscience·D H SmallJ C Bornstein
Apr 3, 2003·Neuron·Flavio KamenetzRoberto Malinow
Jun 19, 2003·The Journal of Physiology·Carl HolmgrenYuri Zilberter
Aug 12, 2003·Cell Calcium·Mark P Mattson, Sic L Chan
Oct 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Gonçalo Castelo-BrancoErnest Arenas
Mar 10, 2004·Neurobiology of Disease·I GurevicieneH Tanila
May 28, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tibor HarkanyYuri Zilberter
Jun 3, 2004·Annals of Neurology·Fabrizio TrincheseOttavio Arancio

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Citations

Nov 30, 2010·Nature·Moustapha CisséLennart Mucke
Mar 10, 2010·The Journal of Biological Chemistry·Angelo DemuroGrace E Stutzmann
Oct 5, 2010·Brain : a Journal of Neurology·Koen BossersDick F Swaab
Apr 5, 2011·Brain : a Journal of Neurology·Jan MulderTibor Harkany
Mar 29, 2008·PLoS Computational Biology·Isaac ShemerSten Grillner
Aug 27, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicola OrigliaLuciano Domenici
May 6, 2014·Neurobiology of Aging·Vered KellnerEdward A Stern
Dec 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jonathan T TingJane M Sullivan
May 31, 2016·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Shlomit BekerEdward A Stern
Sep 16, 2008·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Armen A GaloyanDavit O Abrahamyan
Aug 5, 2008·Trends in Neurosciences·Ilya Bezprozvanny, Mark P Mattson
Apr 7, 2007·Annals of the New York Academy of Sciences·Jaime GrutzendlerWen-Biao Gan
Sep 15, 2009·Experimental Neurology·Massimo TabatonLuca Giliberto
Sep 23, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mohamady El-GabyOle Paulsen
Jul 27, 2007·Biological Psychiatry·Fortunato BattagliaRalph A Nixon
Sep 29, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Grace E Stutzmann
Oct 30, 2018·Journal of Alzheimer's Disease : JAD·Francesco Di LorenzoGiacomo Koch
Mar 21, 2007·Synapse·Kodeeswaran ParameshwaranVishnu Suppiramaniam
Aug 28, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wei-Qin ZhaoWilliam L Klein
Jul 31, 2009·Journal of Neuroscience Research·George M AlleyDebomoy K Lahiri
Dec 18, 2012·Journal of Neurochemistry·Misha ZilberterYuri Zilberter
Feb 1, 2011·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Alán AlpárUlrich Gärtner
Sep 17, 2016·Journal of Alzheimer's Disease : JAD·Irina GurevicieneHeikki Tanila
Jan 11, 2017·PloS One·Anna PapazoglouMarco Weiergräber
Dec 7, 2020·Brain : a Journal of Neurology·Joana B PereiraOskar Hansson
Feb 10, 2021·Proceedings of the National Academy of Sciences of the United States of America·Zsófia HevesiAlán Alpár
Jul 6, 2021·Frontiers in Molecular Neuroscience·Yuniesky Andrade-Talavera, Antonio Rodríguez-Moreno

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