Non-functioning pituitary adenomas: endocrinological and clinical outcome after transsphenoidal and transcranial surgery

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
M Wichers-RotherB Stoffel-Wagner

Abstract

To study improvement of anterior pituitary function after transsphenoidal and transcranial surgery of non-functioning (NF) pituitary macro- and microadenomas. We retrospectively examined 155 patients with NF adenomas preoperatively and 3 months, 1 year and 2 years postoperatively. 130 patients harboured a macroadenoma, 109 underwent transsphenoidal (group one), 21 transcranial surgery (group two). 25 patients presented a microadenoma (transsphenoidal surgery, group three). Endocrine studies included basal serum levels and dynamic testing of anterior pituitary partial function. Clinical symptoms and hormone replacement therapy were documented. Preoperatively, in group one, two and three, somatotropic function was impaired in 85, 90 and 80 %, gonadotropic in 61, 57 and 24 %, corticotropic in 31, 38 and 28 %, thyreotropic in 32, 38 and 12 % and lactotropic in 22, 38 and 32 % cases, respectively. Pituitary functions did not improve significantly after transsphenoidal or transcranial surgery. Presurgically, 63, 62 and 0 % patients complained about visual impairments, 60, 48 and 40 % about headache, 53, 24 and 36 % about fatigue and 28, 33 and 20 % about disturbance of cycle or potency. After transsphenoidal surgery, impaired vision,...Continue Reading

Citations

Mar 3, 2007·Aging Clinical and Experimental Research·Patrizia Del MonteDonatella Bernasconi
Apr 19, 2008·Pituitary·Michael Buchfelder, Juergen Kreutzer
Apr 4, 2016·Clinical Neurology and Neurosurgery·Junxiang PengYuping Peng
Feb 7, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Israel B OrijaAmir H Hamrahian
May 13, 2008·La Revue de médecine interne·B GranelY Frances
May 1, 2007·Lancet·Harald Jörn SchneiderEzio Ghigo
Aug 19, 2007·Clinical Endocrinology·N KaravitakiJ A H Wass
May 12, 2010·Clinical Endocrinology·Lucy Ann BehanAmar Agha
Aug 15, 2012·Clinical Endocrinology·Carmela CaputoWarrick J Inder
Jun 14, 2015·Annales d'endocrinologie·Frederic CastinettiJacqueline Trouillas
Aug 20, 2014·Endocrinology, Diabetes & Metabolism Case Reports·Roberto SalvatoriAlbert Beckers
Mar 5, 2015·International Journal of Endocrinology·Guadalupe VargasMoisés Mercado
Jul 23, 2011·Arquivos brasileiros de endocrinologia e metabologia·Rogerio Silicani Ribeiro, Julio Abucham
Oct 4, 2008·The Journal of International Medical Research·Hanbin WangQi Pang
Mar 2, 2006·The Journal of Clinical Endocrinology and Metabolism·O M DekkersJ A Romijn
Feb 6, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Paul MarcetFernando L Vale
Aug 7, 2008·The Journal of Clinical Endocrinology and Metabolism·O M DekkersJ A Romijn
Sep 10, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ambika BabuLeon Fogelfeld
Dec 17, 2019·The Journal of Neuroscience Nursing : Journal of the American Association of Neuroscience Nurses·Min Kyeong JangSanghee Kim
May 11, 2010·Current Opinion in Endocrinology, Diabetes, and Obesity·Kiarash ShahlaieDaniel F Kelly
Jun 22, 2006·The Journal of Clinical Endocrinology and Metabolism·O M DekkersJ A Romijn
Dec 6, 2018·Hormones : International Journal of Endocrinology and Metabolism·I KaramouzisGianluca Aimaretti
Jul 9, 2020·Clinical Medicine Insights. Endocrinology and Diabetes·Mussa H AlMalkiSalem A Beshyah
Mar 1, 2007·Expert Review of Endocrinology & Metabolism·Michael BuchfelderChristopher Nimsky
Oct 23, 2020·Endocrine·Liana Lumi OginoMônica R Gadelha

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