Non-Gaussian diffusion alterations on diffusion kurtosis imaging in patients with early Alzheimer's disease

Neuroscience Letters
Lixiang YuanHongyan Ni

Abstract

To evaluate non-Gaussian diffusion changes of the whole-brain and its correlation with cognitive performance in patients with early Alzheimer's disease (AD), using diffusion kurtosis imaging (DKI). Twenty-six patients with early AD and twenty-six normal controls underwent diffusion imaging. Seven parametric maps were calculated from multiple b-value diffusion data, including mean kurtosis (MK), axial kurtosis (AK), radial kurtosis (RK), fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AxD) and radial diffusivity (RD). Voxel-based analyses were performed to evaluate the group difference between the AD patients and normal controls. Then correlation between the diffusion parameters (MK, FA and MD) and cognitive performance were analyzed in AD patients. For AD patients, increased MD, AxD and RD were found in white matter (WM), including the genu of corpus callosum, bilateral cingulate bundle, bilateral temporal and frontal WM, and were also found in gray matter (GM), including the bilateral temporal GM, parahippocampal gyrus, hippocampus, cingulate gyrus, thalamus, and amygdala. These regions were partially overlapped with those showing decreased FA, MK, AK and RK. However, only kurtosis indices could detect th...Continue Reading

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Citations

May 5, 2017·Journal of Magnetic Resonance Imaging : JMRI·Alexandra LjimaniHans-Jörg Wittsack
Jun 19, 2017·Journal of Gastrointestinal Cancer·Mecit Kantarci, Berhan Pirimoglu
Mar 27, 2020·Neural Regeneration Research·Koji KamagataShigeki Aoki
Jun 3, 2021·International Journal of Molecular Sciences·Koji KamagataShigeki Aoki
Jun 25, 2021·Frontiers in Oncology·Winnie Wan Yee TsoGodfrey Chi-Fung Chan

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