Non-Gaussianity, population heterogeneity, and transient superdiffusion in the spreading dynamics of amoeboid cells

Physical Chemistry Chemical Physics : PCCP
Andrey G CherstvyRalf Metzler

Abstract

What is the underlying diffusion process governing the spreading dynamics and search strategies employed by amoeboid cells? Based on the statistical analysis of experimental single-cell tracking data of the two-dimensional motion of the Dictyostelium discoideum amoeboid cells, we quantify their diffusive behaviour based on a number of standard and complementary statistical indicators. We compute the ensemble- and time-averaged mean-squared displacements (MSDs) of the diffusing amoebae cells and observe a pronounced spread of short-time diffusion coefficients and anomalous MSD-scaling exponents for individual cells. The distribution functions of the cell displacements, the long-tailed distribution of instantaneous speeds, and the velocity autocorrelations are also computed. In particular, we observe a systematic superdiffusive short-time behaviour for the ensemble- and time-averaged MSDs of the amoeboid cells. Also, a clear anti-correlation of scaling exponents and generalised diffusivity values for different cells is detected. Most significantly, we demonstrate that the distribution function of the cell displacements has a strongly non-Gaussian shape and-using a rescaled spatio-temporal variable-the cell-displacement data colla...Continue Reading

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Citations

Feb 9, 2019·Soft Matter·Andrey G CherstvyRalf Metzler
Apr 15, 2019·The Journal of Chemical Physics·Samudrajit ThapaRalf Metzler
Aug 16, 2019·Proceedings of the National Academy of Sciences of the United States of America·Susan E LeggettIan Y Wong
Nov 11, 2019·Scientific Reports·Taejin KwonBong June Sung
Oct 20, 2020·Physical Chemistry Chemical Physics : PCCP·Amanda Díez FernándezMichael W Finnis
Jul 1, 2021·Mathematical Medicine and Biology : a Journal of the IMA·M ScottR N Bearon

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