Non-genomic Actions of Thyroid Hormones Regulate the Growth and Angiogenesis of T Cell Lymphomas

Frontiers in Endocrinology
F CayrolG A Cremaschi

Abstract

T-cell lymphomas (TCL) are a heterogeneous group of aggressive clinical lymphoproliferative disorders with considerable clinical, morphological, immunophenotypic, and genetic variation, including ~10-15% of all lymphoid neoplasms. Several evidences indicate an important role of the non-neoplastic microenvironment in promoting both tumor growth and dissemination in T cell malignancies. Thus, dysregulation of integrin expression and activity is associated with TCL survival and proliferation. We found that thyroid hormones acting via the integrin αvβ3 receptor are crucial factors in tumor microenvironment (TME) affecting the pathophysiology of TCL cells. Specifically, TH-activated αvβ3 integrin signaling promoted TCL proliferation and induced and an angiogenic program via the up-regulation of the vascular endothelial growth factor (VEGF). This was observed both on different TCL cell lines representing the different subtypes of human hematological malignancy, and in preclinical models of TCL tumors xenotransplanted in immunodeficient mice as well. Moreover, development of solid tumors by inoculation of murine TCLs in syngeneic hyperthyroid mice, showed increased tumor growth along with increased expression of cell cycle regulators....Continue Reading

References

Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·S P Tokmakidis, L A Léger
Oct 1, 1995·The Journal of Clinical Investigation·P C BrooksD A Cheresh
May 2, 1997·International Journal of Cancer. Journal International Du Cancer·R MaxR M De Waal
Feb 15, 2001·Seminars in Cancer Biology·I Stamenkovic
Jan 12, 2002·Nature Medicine·Louise E ReynoldsKairbaan M Hodivala-Dilke
Aug 15, 2003·The Journal of Biological Chemistry·Xiaowu LiDaniel M Ramos
Aug 20, 2003·The Journal of Clinical Investigation·Mitchell A Lazar
Mar 24, 2005·Neuroimmunomodulation·Alicia Juana KlechaGraciela Alicia Cremaschi
Oct 19, 2005·International Journal of Cancer. Journal International Du Cancer·Tuomo T HörkköMarkus J Mäkinen
Feb 24, 2006·American Journal of Physiology. Cell Physiology·María Laura Barreiro ArcosGraciela A Cremaschi
Aug 22, 2006·Current Opinion in Cell Biology·Melinda LarsenKenneth M Yamada
Oct 5, 2006·Anti-cancer Agents in Medicinal Chemistry·Weibo Cai, Xiaoyuan Chen
Jul 21, 2007·Circulation Research·Ganapati H MahabeleshwarTatiana V Byzova
Jan 29, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jianxun LeiDavid H Ingbar
Jun 6, 2008·Endocrine-related Cancer·Hira Lal GoelLucia R Languino
Jul 16, 2008·Current Opinion in Pharmacology·Valerie G Brunton, Margaret C Frame
Jul 29, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Rita SilvaLouise E Reynolds
Jan 22, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alf Inge HellevikLars J Vatten
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manal M HassanJames L Abbruzzese
Dec 24, 2009·Nature Reviews. Cancer·Jay S Desgrosellier, David A Cheresh
Jan 7, 2010·Endocrine Reviews·Sheue-Yann ChengPaul J Davis
Jan 19, 2010·Expert Reviews in Molecular Medicine·Christopher S Stipp
Feb 6, 2010·The Journal of Clinical Endocrinology and Metabolism·M YalcinS A Mousa
Mar 2, 2010·Thyroid : Official Journal of the American Thyroid Association·Murat YalcinShaker A Mousa

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Citations

Sep 3, 2020·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Marwa S Hamza, Shaker A Mousa
Aug 15, 2020·Thyroid : Official Journal of the American Thyroid Association·Valerie Anne GaltonArturo Hernandez
Jun 14, 2020·International Journal of Molecular Sciences·Marco GiammancoItalia Di Liegro
Nov 27, 2020·Frontiers in Endocrinology·Cole K Deal, Helene Volkoff
Dec 20, 2020·Differentiation; Research in Biological Diversity·Paul S CookeEllis R Levin
May 1, 2021·Journal of Clinical Medicine·Uri AbadiOsnat Ashur-Fabian
Jun 3, 2021·Cancers·Gabriella SchieraItalia Di Liegro

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Methods Mentioned

BETA
GTPase
xenograft
biopsies
xenografts

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