Non-genomic effects of aldosterone: new actions and questions

Trends in Endocrinology and Metabolism : TEM
Tae-Yon Chun, J Howard Pratt

Abstract

Although the classical actions of aldosterone are mediated through genomic pathways, there is a growing recognition of important nongenomic responses to aldosterone. New data are presented from two laboratories showing a nongenomic effect of aldosterone to activate protein kinase C (PKC) in heart and kidney. Among the actions of PKC is the stimulation of transcription factors, raising the question of whether there is an inter-relationship of nongenomic with genomic influences--aldosterone induced nongenomic effects might modulate genomic effects. This expanded role of aldosterone will require exploration in future studies.

Associated Clinical Trials

References

Dec 11, 2002·Journal of Biochemistry·Yoshiko Akita
Nov 8, 2003·Endocrinology·Anastasia S MihailidouJohn W Funder
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christian WinterCarsten A Wagner

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Citations

Mar 23, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Anna GromotowiczEwa Chabielska
Nov 16, 2005·Hypertension·Peter J Fuller, Morag J Young
Jan 21, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Jun SuzukiMasatsugu Horiuchi
Feb 14, 2006·The Journal of Biological Chemistry·Robert S EdingerJohn P Johnson
Aug 30, 2013·American Journal of Physiology. Renal Physiology·Nils van der LubbeEwout J Hoorn
Mar 9, 2007·American Journal of Physiology. Renal Physiology·Akiyuki TarunoYoshinori Marunaka
Mar 30, 2007·Clinical Science·Morag J YoungAmanda J Rickard
Jun 26, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yoshino MinouraYouichi Kobayashi

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