Non-genomic immunosuppressive actions of progesterone inhibits PHA-induced alkalinization and activation in T cells

Journal of Cellular Biochemistry
Eileen Jea ChienChia-Hsun Wu

Abstract

Progesterone is an endogenous immunomodulator, and can suppress T-cell activation during pregnancy. When analyzed under a genome time scale, the classic steroid receptor pathway does not have any effect on ion fluxes. Therefore, the aim of this study was to investigate whether the non-genomic effects on ion fluxes by progesterone could immunosuppress phytohemagglutinin (PHA)-induced human peripheral T-cell activation. The new findings indicated that, first, only progesterone stimulated both [Ca2+]i elevation and pHi decrease; in contrast, estradiol or testosterone stimulated [Ca2+]i elevation and hydrocortisone or dexamethasone stimulated pHi decrease. Secondly, the [Ca2+]i increase by progesterone was dependent on Ca2+ influx, and the acidification was blocked by Na+/H+ exchange (NHE) inhibitor, 3-methylsulphonyl-4-piperidinobenzoyl, guanidine hydrochloride (HOE-694) but not by 5-(N,N-dimethyl)-amiloride (DMA). Thirdly, progesterone blocked phorbol 12-myristate 13-acetate (PMA) or PHA-induced alkalinization, but PHA did not prevent progesterone-induced acidification. Fourthly, progesterone did not induce T-cell proliferation; however, co-stimulation progesterone with PHA was able to suppress PHA-induced IL-2 or IL-4 secretion ...Continue Reading

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Citations

Mar 12, 2016·General and Comparative Endocrinology·Rohini R NairKiran Singh
Mar 23, 2012·The Journal of Obstetrics and Gynaecology Research·Mahmood BozorgmehrSeyed Mohammad Moazzeni
Feb 10, 2010·Journal of Cellular Physiology·Ching-Pang ChangEileen Jea Chien
Feb 3, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·A AreiaA Mota-Pinto
Jun 12, 2013·Expert Opinion on Therapeutic Targets·Florian LangChristos Stournaras
May 23, 2014·Frontiers in Immunology·Anne SchumacherAna Claudia Zenclussen
Aug 12, 2016·Journal of Cellular Physiology·Yuetao ZhouFlorian Lang
Feb 27, 2007·Journal of Cellular Physiology·Eileen Jea ChienMing-Ta Hsu
Jul 6, 2021·European Journal of Immunology·Georgia PapapavlouJan Ernerudh
Jun 20, 2012·Journal of Reproductive Immunology·Kalidou NdiayeJoy L Pate

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